蘭州大學(xué)

姓 名: 高麗萍
Name: Liping Gao
職 務(wù)：教授
Duty: Professor
E-mail：gaolp@lzu.edu.cn

一、科研方向

主要研究活性氧、活性氮和抗氧化劑在人類疾病，特別是在腫瘤和神經(jīng)退行性疾病中的作用。一個(gè)方向是研究腫瘤細(xì)胞死亡和藥物抗性的分子機(jī)制，側(cè)重于腫瘤化療多藥抗性的氧化還原調(diào)節(jié)；篩選有效的抗癌藥物也是研究目標(biāo)之一。另一個(gè)方向是利用體外和體內(nèi)方法來研究神經(jīng)退行性疾病的分子機(jī)制和篩選有效的神經(jīng)保護(hù)藥物。
Research Interests：
My research interests are in the role of reactive oxygen species, reactive nitrogen species and  antioxidants in human diseases, especially cancer and neurodegenerative diseases. One area focuses on the molecular mechanism of tumor cell death and drug resistance, especially redox regulation of multidrug resistance in cancer chemotherapy. In addition, screening effective anticancer drug is also one of our goals. The other area focuses on the use of in vitro, ex vivo systems to study the molecular mechanism of neurodegenerative diseases and screening effective neuroprotective drug。

二、榮譽(yù)稱號(hào)及獎(jiǎng)勵(lì)

參加甘肅省自然科學(xué)基金項(xiàng)目《維生素E和硒對(duì)耐藥白血病細(xì)胞凋亡調(diào)控基因及耐藥基因表達(dá)影響研究》，獲2007年度甘肅醫(yī)學(xué)科技獎(jiǎng)二等獎(jiǎng)。
參加甘肅省自然科學(xué)基金項(xiàng)目《復(fù)方沙棘和沙棘籽油對(duì)大鼠缺血性腦梗塞的防護(hù)作用及其機(jī)理探討》，獲2002年度甘肅醫(yī)學(xué)科技獎(jiǎng)三等獎(jiǎng)。
honors and awards：
Participation in the project ‘The effects of Vitamin E and Selenium on expression of apoptotic gene and multidrug resistant gene in leukemia cells’ funded by science and technology department of Gansu province and won the second grade prize from Gansu Medical Association。
Participation in the project ‘The protection and mechnism of Compound Hippophae rhamnoides L. and Hippophae rhamnoides L.seed oil on ischemic cerebral infarction in rats’ funded by science and technology department of Gansu province and won the third grade prize from Gansu Medical Association。

三、個(gè)人簡歷

2004年11月至今蘭州大學(xué)基礎(chǔ)醫(yī)學(xué)院生物化學(xué)與分子生物學(xué)研究所。
2006年2月-2007年6月    臺(tái)灣長庚大學(xué)醫(yī)學(xué)生物技術(shù)研究所博士后。
1999年7月-2004年10月  蘭州醫(yī)學(xué)院生物化學(xué)和分子生物學(xué)教研室。
2003年12月-2004年3月  日本山形大學(xué)分子病理生物化學(xué)短期研修。
2001年9月-2004年6月   蘭州大學(xué)細(xì)胞生物學(xué)專業(yè)博士研究生。
1996年9月-1999年6月   蘭州醫(yī)學(xué)院藥理學(xué)專業(yè)碩士研究生。
1993年7月-1996年5月   蘭州手扶拖拉機(jī)廠職工醫(yī)院。
1989年9月-1993年6月   蘭州醫(yī)學(xué)院藥學(xué)院。
Resume：
Aug. 2004 ? Present   Associate Professor, Institute for Biochemistry and Molecular Biology, School of Medical Sciences, Lanzhou University。
Feb. 2006 ? Jun. 2007     Post-doctoral fellow   Graduate Institute of Medical Biotechnology and Department of Medical Biotechnology and Laboratory Science, Chang Gung   University, Taiwan。  
Jul. 1999 ? Oct. 2004   Associate Professor, Instructor    Department of Biochemistry and Molecular Biology, Lanzhou Medical College
Sept. 2001 ? Jun. 2004   Ph. D  Cell Biology   School of Life Sciences, Lanzhou University。
Dec. 2003 ? Mar. 2004    Visiting Scholar   Department of Molecular and Pathological Biochemistry, School of Medicine, Yamagata University, Japan
Sept. 1996 ? June 1999    M.S  Pharmacology   Department of Pharmacology, Lanzhou Medical College。
July 1993 ? May 1996   Apothecary   Hospital of Lanzhou tractor factory, Lanzhou。
Sept. 1989 ? June 1993    B. S.  Pharmacy   Department of pharmacy, Lanzhou Medical College。

四、發(fā)表論文

SHUUAI Xue-hong, HU Ting-jun, CHEN Jiong-ran, GAO Liping Immune function and antioxidant capability in mice. Acta Veterinaria et Zootechnica Sinica. 2008, 39(7):1000-1004。
Liping Gao, Chengshang Yuan,  Zhongjian Jia,  Hulai Wei, Rongliang Zheng   Protective effects of verbascoside on hydrogen peroxide-induced cytotoxicity and apoptosis in astrocytes. Progress In Biochemistry and Biophysics. 2008, 35(Suppl): 210-211。
Gao Liping, Wei Hulai, Jing Tao, Wu Yongjie, Chen Jing, Sun Jing, Yi Juan , Zhao Huaishun.   siRNAs silence expression of mdr1 gene and reverse drug-resistance in K562/ADM cells  China Oncology  2007, 17(1): 58-61。
Wei Hulai, Gao Liping, Jing Tao, Zhao Huaishun, Yi Juan, Sun Jin, Han Jian.   siRNA silences mdr1 gene expression and reverses apoptosis resistance of K562/ADM cells line. Chinese Journal of Hematology.  2007, 28(6): 388-390。
Wei Hulai, Zhang Zhewen, Gao Liping, Li Linjing, Yi Juan, Sun Jing.   Kappa-selenocarrageenan overcomes apoptosis resistance in multidrug-resistant K562/ADM cells bydown-regulating expression of mdr1 gene and its product P-glycoprotein. Journal of Modern Oncology. 2006 14(12): 1489-1492。
DONG Jian-yong,JIA Zhong-jian, GAO Li-ping   Effects of Flavonoids from Hypericum Attemuatum on oxidative stress injury of PC12 cell DNA. Shanghai Journal of Traditional Chinese Medicine. 2006, 40(12):68-70。
Gao LP, Wei HL, Zhao HS, Xiao SY, Zheng RL.   Antiapoptotic and antioxidant effects of rosmarinic acid in astrocytes. Pharmazie. 2005, 60(1): 62-65。
Zhang Wenbin, Cheng Tijuan, Gao Liping.   Protective effect of compound hippophae rhamnoids L.granule on ischemic injury in cultured rat cortical neurons. Chinese Journal of clinical Pharmacology Therapeutics. 2004, 9 (2): 189-192。
Gao Liping, Cheng Tijuan, Wang Yibin, Sun Yifang, Zhang Jian.   The preventive function of compound Hippophae rhamnoides L.against ischemic cerebral infarction in rats and mice. Journal of Lanzhou University (Natural Sci.). 2003, 3 (39): 53-56。
Cheng Tijuan, Wang Yibin, Gao Liping, Sun Yifang, Zhang Jian.   The protection of seed oil of Hippophae rharmnoides on ischemic cerebral infarction in Rats. China Journal of Chinese Materia Medica. 2003, 6 (28): 548-550。
Zhang Jun, Hua Yan, WangYuping, Gao Liping, Wei Huilai.   Antioxidant action of Apigenin-quercetin-3, 3’-dimethyl etherhe and quercetagetin-3,6-dimethyl ether-7-o-glucoside in vitro. Pharmacology and Clinics of Chinese Material Medica.  2003, 19 (4): 12-13。
Gao Liping, Cheng Tijuan, Yang Zhiyong, Sun Yifang.   The influence of compound Hippophae rhamnoides L.on MDA of brain, blood coagulation time and platelet number in focal cerebral ischemia rat.  Pharmacology and Clinics of Chinese Material Medica.  2002, 18 (4): 26-28。
Yang Zhiyong, Cheng Tijuan, Gao Liping, Liu Guoqing.   The comparative studies between S. przewalsii maxim and S. miltiorrhize on focal cerebral ischemia and blood rheology of rats. Pharmacology and Clinics of Chinese Material Medica.  2002, 18 (6): 26-28。
Cheng Tijuan, Gao Liping, Wang Yibin, Sun Yifang, Zhang Jian, Li Dongyu.   The effect of seed oil of Hippophae rhamnoides L. (SOHR) on hemorrheology of cerebral infarction in rats.  Pharmacology and Clinics of Chinese Material Medica.  2002, 18(2): 14-15。
Cheng Tijuan, Gao Liping, Wang Yubin, Sun Yifang, Zhang Jian, Li Dongyu.   The influence of seed oil of Hippophae rhamnoides L.on MDA of brain, blood coagulation time and platelet number in focal cerebral ischemia rat.  Journal of Lanzhou University. 2002, 38 (Suppl): 101-103。

五、學(xué)術(shù)團(tuán)隊(duì)

在校： 劉晶晶   熊亮斌