蘭州大學(xué)

學(xué)習(xí)經(jīng)歷

◆2001.9-2005.6蘭州大學(xué)生命科學(xué)院 生物學(xué)國家基地班學(xué)士
◆2005.9-2010.6蘭州大學(xué)和中科院上海有機化學(xué)研究所聯(lián)合陪養(yǎng)化學(xué)生物學(xué)博士

工作經(jīng)歷

◆2010.9-2012.5 德國saarland大學(xué)和 Helmholtz研究所抗感染saar中心藥物生物技術(shù)博士后
◆2013.1至今 蘭州大學(xué)生命科學(xué)院微生物所 副教授
 
教學(xué)及指導(dǎo)研究生情況

指導(dǎo)研究生2名

發(fā)表論文及專著

1. Insight into Bacterial 6-Methylsalicyclic Acid Synthase and Its Engineering to Orsellinic Acid Synthase for Novel Spirotetronates Generation.
Wei Ding, Chun Lei, Qingli He, Yurong Bi , Wen Liu.
Chemistry & Biology, 2010, 17, 495–503 （IF=6.5）
2. Biosynthesis of 3-Methoxy-5-Methyl Naphthoic Acid and Its Incorporation into the Antitumor antibiotic Azinomycin B.
Wei Ding, Wei Deng, Manchen Tang, Gongli Tang, Yurong Bi, Wen Liu.
Molecular BioSystems, 2010, 6, 1071-1081 （IF=4.5）
3. Nitric oxide mediates abscisic acid induced thermotolerance in the calluses
from two ecotypes of reed under heat stress.
Lili Song, Wei Ding, Juan Shen, Zhiguo Zhang, Yurong Bi, Lixin Zhang.
Plant Science, 2008, 175 (6): 826-832.（Co-first author）（IF=2.5）
4. Effect of abscisic acid on heat stress tolerance in the calli from two ecotypes of Phragmites communis
Wei Ding, Lili Song, Yurong Bi.
Biologia Plantarum, 2010, 54 (1–4): 607-613（IF=1.97）
5. Genetic characterization of the Saframycin A gene cluster from Streptomyces lavendulae NRRL11002 revealing a NRPS system for the characteristic bisquinone biosynthesis in an iterative manner.
Lei Li, Wei Deng, Jie Song, Wei Ding, Qunfei, Zhao, Weiwen Song, Gongli Tang, Wen Liu.
Journal of Bacteriol, 2008, 290, 251–263.
6. Characterization of the Azinomycin B Biosynthetic Gene Cluster Revealing a Different Iterative Type I Polyketide Synthase for Naphthoate Biosynthesis.
Qunfei Zhao, Qingli He, Wei Ding, Mancheng Tang, Qianjin Kang, Yi Yu, Wei Deng, Qi Zhang, Jie Fang, Gongli Tang, and Wen Liu.
Chemistry & Biology, 2008, 15, 693-705.
7. Aromatic polyketides produced by bacterial Iterative type I polyketide synthases
Qi Zhang, Bo Pang, Wei Ding, and Liu, Wen*
ACS Catal., 2013, 3 (7), pp 1439–1447
8. Nitric oxide protects against oxidative stress under heat stress in the calluses from two ecotypes of reed.
Lili Song, Wei Ding, Mingui Zhao, Baoteng Sun, Lixin Zhang.
Plant Science, 2006, 171 (4): 449-458.
9. Engineer 6-MSAS and Combinatorial synthesis NewSpirotrtronates antibiotics with improved bioactivity
Wen Liu, wei ding
(Chinese patent No. : 200910247567.8)

研究方向

微生物天然產(chǎn)物（抗生素）的宏基因組發(fā)掘（genome mining）， 重要生物活性抗生素的生物合成機制和新型酶催化反應(yīng)機制研究 ，重要臨床藥物中間體的生物轉(zhuǎn)化， 抗生素工業(yè)菌種的基因工程改造。