北京大學(xué)

王欣: 博士、副教授、碩士生導(dǎo)師

Tel: 010-82801504

Email: xinwang@bjmu.edu.cn

1991年獲北京醫(yī)科大學(xué)應(yīng)用化學(xué)專業(yè)學(xué)士學(xué)位，2002年獲北京大學(xué)藥學(xué)院藥物化學(xué)碩士學(xué)位，2010年獲得北京大學(xué)藥學(xué)院化學(xué)生物學(xué)專業(yè)博士學(xué)位。2004年被聘為副教授，2005年被聘為碩士生導(dǎo)師。2005年1月-2005年6月在悉尼大學(xué)做訪問學(xué)者。

科研：主要研究方向?yàn)殡s環(huán)化合物的設(shè)計、合成及對神經(jīng)系統(tǒng)疾病的作用；有機(jī)合成新方法的研究。已在Chem. Commun.，Bioorg. Med. Chem. Lett., Tetrahedron, Rapid commun. mass spectrum.等國際雜志發(fā)表文章二十余篇，另有三項發(fā)明專利。主持完成了一項國家自然科學(xué)基金面上項目，《哌嗪季銨鹽類非成癮性鎮(zhèn)痛藥物研究》獲2005年北京市科技進(jìn)步二等獎，為第二完成人。

教學(xué)：多年來一直從事有機(jī)化學(xué)教學(xué)工作，曾獲2003年及2007年北京大學(xué)藥學(xué)院青年教師講課比賽一等獎，北京大學(xué)第四屆及第七屆青年教師講課比賽三等獎。《基礎(chǔ)有機(jī)化學(xué)》課程獲北京大學(xué)醫(yī)學(xué)部精品課程，為課程負(fù)責(zé)人。參編譯著《雜環(huán)化學(xué)》。

代表性文章：

1)Xin Wang, Yaowu Sha, Zemei Ge, Wei Wang, Runtao Li*. Fragmentation patterns of novel dithiocarbamate derivatives with pharmaceutical activity under electrospray ionization tandem mass spectrometry conditions. Rapid commun. mass spectrum., 2011, 25(2): 349-354.

2)Xin Wang, Ang Li, Wei Wang, Runtao Li*. Fragmentation patterns of novel dispirocyclopiperazinium dibromides with strong analgesic activity under electrospray ionization tandem mass spectrometry conditions. Journal of Chinese pharmaceutical sciences, 2011, 20(1): 42-46.

3)Jin-ming Liu, Xin Wang, Ze-mei Ge, Qi Sun, Tie-ming Cheng, Run-tao Li *。Solvent-free organocatalytic Michael addition of diethyl malonate to nitroalkenes: the practical synthesis of Pregabalin and g-nitrobutyric acid derivatives. Tetrahedron 2011, 67 (3): 636-640.

4)王欣,劉文俊,李剛,葉加,程鐵明,李潤濤*. 雙螺環(huán)哌嗪季銨鹽類化合物的合成及鎮(zhèn)痛活性研究 有機(jī)化學(xué)，2010, 30(10): 1559-1562.

5)Junfeng Wang, Xin Wang, Zemei Ge,* Tieming Cheng and Runtao Li.* Highly enantioselective Michael addition of cyclopentanone with chalcones via novel di-iminium mechanism. Chem. Commun., 2010, 46: 1751-1753.

6)Xin Ai, Xin Wang*, Jin-ming Liu, Ze-mei Ge, Tie-ming Cheng, Run-tao Li* An effective Aza-Michael addition of aromatic amines to electron-deficient alkenes in alkaline Al2O3. Tetrahedron, 2010, 66 (29): 5373-5377.

7)Shuai Xia, Xin Wang,*  Ze-mei Ge, Tie-ming Cheng, Run-tao Li* An Efficient Synthesis of aryldithiocarbamic acid esters from Michael addition of electron-deficient alkenes with arylamines and CS2 in solid media alkaline Al2O3  Tetrahedron, 2009, 65 (5): 1005-1009

8)Ang Li, Xin Wang, Cai-Qin Yue, Jia Ye, Chang-Ling Li and Run-Tao Li* Unique spirocyclopiperazinium salt. Part 4: Modification of dispirocyclopiperazinium (DSPZ) salts as analgesics，Bioorg. Med. Chem. Lett., 2007, 17: 5078–5081;

9)Xin Wang, Yaowu Sha, Xueling Hou, Runtao Li. Electrospray ionization tandem mass spectrometric analysis of fragmentation patterns of dithiocarbamate derivatives. Rapid commun. mass spectrum., 2006; 20: 719-722.

10)Xin Wang, Yaowu Sha, Runtao Li. Fragmentation patterns of novel dispirocyclopiperazinium dibromides with strong analgesic activity under electrospray ionization tandem mass spectrometry conditions. Rapid commun. mass spectrum., 2004; 18: 829-833.

11)Xin Wang, Yaowu Sha, Runtao Li. Fragmentation patterns of novel dispirocyclopiperazinium dibromides with strong analgesic activity under electrospray ionization tandem mass spectrometry conditions. Int. J Mass Spectrom., 2004; 235: 111–115.

12)Xin Wang, Feng-Li Gao, Hong-Bin Piao, Tie-Ming Cheng, Run-Tao Li. Unique spirocyclo- piperazinium salt. Part 2: Synthesis and structure-activity relationship of dispirocyclo- piperazinium salts as analgesics. Bioorg. Med. Chem. Lett., 2003, 13:1729-1732.

13)  Feng-Li Gao, Xin Wang, Hong-Mei Zhang, Tie-Ming Cheng, Run-Tao Li. Unique spirocyclo- piperazinium salt I: Synthesis and structure-activity relationship of spirocyclopiperazinium salts as analgesics. Bioorg. Med. Chem. Lett., 2003, 13: 1535-1537.

14) Jing-Chao Dong, Xin Wang, Run-Tao Li, Hong-Mei Zhang, Tie-Ming Cheng, and Chang-Ling Li. Synthesis and analgesic activity of hydrochlorides and quaternary ammoniums of epibatidine incorporated with amino acid ester. Bioorg. Med. Chem. Lett., 2003, 13: 4327-4329.