北京大學(xué)

李慶：副教授，碩士生導(dǎo)師

電話：010-82801714

E-mail: qli@bjmu.edu.cn

通信地址：北京市海淀區(qū)學(xué)院路38號藥學(xué)樓522室 郵編：100191

1983.9-1987.7，蘭州大學(xué)化學(xué)系有機(jī)化學(xué)專業(yè)，學(xué)士學(xué)位；1987.8-1991.11，大慶石油化工總廠研究院，助理工程師；1991.11-1996.8，大慶油田設(shè)計院，工程師；1993.9-1996.7，天津大學(xué)化學(xué)系精細(xì)化工專業(yè)，碩士學(xué)位；1996.9-1999.7，北京醫(yī)科大學(xué)藥學(xué)院藥物化學(xué)專業(yè)，博士學(xué)位。自1999年至今，北京大學(xué)醫(yī)學(xué)部藥學(xué)院化學(xué)生物學(xué)系工作。目前主要開展抗粘附多價寡糖及糖-肽雜合物的合成研究, 設(shè)計合成了結(jié)構(gòu)多樣的多價寡糖及糖-肽雜合物，其中四價乳糖Gu-4具有良好的抗白細(xì)胞-內(nèi)皮細(xì)胞粘附活性，作為藥物候選分子在對大鼠的重癥燒傷休克、膿毒癥及關(guān)節(jié)炎的治療中已顯示了良好的效果。

目前在研課題：

1.乳糖衍生物抗粘附新靶點的發(fā)現(xiàn)及其抗炎機(jī)制的研究 (90713004)，國家自然科學(xué)基金重大研究計劃“基于化學(xué)小分子探針的信號轉(zhuǎn)導(dǎo)過程研究”培育項目，2008.1~2010.12。

2. 新型“多配體”型雜合糖簇的設(shè)計、合成及“雜簇螯合效應(yīng)”的探索(21172015)，國家自然科學(xué)基金面上項目，2012.01~2015.12。。

近年發(fā)表的相關(guān)論文：

1. Qing Li, Bin Su, Hui Li, Xiang-Bao Meng, Meng-Shen Cai, Zhong-Jun Li, Ta-Lin Suo, Rou-Li Zhou, Synthesis and potential activity in anti-metastasis of spacer armed 2-acetamido-2-deoxy-4-O-b-D-galactopyranosyl-D-glucosides and their dimers, Carbohydrate Research, 2003, 338, 207-217.

2. Shu Chun Li, Li Min Niu, Hui Li, Zhong Jun Li, Qing Li*, Synthesis of RGD-aPEG-Lactoside, a Potential Anti-metastasis Glycoconjugate, Chin. Chem. Lett., 2004, 15, 532-534.

3. Zhao-Jun Yin, Qing Li*, Xiang-Bao Meng and Zhong-Jun Li*, Design and Synthesis of Novel Multivalent Mannosides Targeting Mannose Receptor, Carbohydrate Research, 2007, 342, 2729-2734.

4. Chen Li, Xiang-Bao Meng, Xiao-Feng Jin, Zhong-Jun Li and Qing Li* , Synthesis of allyl 4-O-{3-deoxy-3-[4-benzylaminocarbonyl-1H-(1,2,3)-triazol-1-yl]-β-D-galactopyranosyl}-2-deoxy-2-acetamido-β-D-glucopyranoside as a potential inhibitor of   galectin-3, Journal of Chinese Pharmaceutical Sciences, 2008, 17, 209-214.

5. Zhihui Zhao & Qing Li & Jiale Hu & Zhongjun Li & Jinghua Liu & Aihua Liu & Peng Deng & Lin Zhang & Xiaowei Gong & Kesen Zhao & Shuangquan Zhang & Yong Jiang, Lactosyl derivatives function in a rat model of severe burn shock by acting as antagonists against CD11b of integrin on leukocytes, Glycoconjugate J., 2009, 26, 173-188.

6.Yu Zheng, Xiang-bao Meng, Shu Chun Li, He-Qing Hang, Zhong-jun Li*, Qing Li*

Synthesis and anti-tumor activities of 5-carbohydrate modified cyclophosphamide derivates, Journal of Chinese Pharmaceutical Sciences, 2010, 19, 327-340.

7.  Qing Li, Yuetao Zhao, Xiangbao Meng, Tingting Yan, Zhihui Zhao, Zhongjun Li, Synthesis of two multivalent lactosides with anti-adhesive activity and their fluorescein-labeled and biotin-labeled derivatives, Journal of Chinese Pharmaceutical Sciences, 2011, 20, 325-334.

8．李中軍, 李慶，趙智輝，孟祥豹，李樹春,一類抗粘附活性的乳糖簇及其熒光標(biāo)記物， 中國專利ZL 200610078665X.

9．趙智輝，陳元，褚鍵，王良哲，李中軍, 李慶，乳糖衍生物的新用途，中國專利 ZL 03112879.3.