重慶大學(xué)

梅虎：主要從事藥物設(shè)計(jì)、藥物基因組學(xué)、生物信息學(xué)等領(lǐng)域研究。先后在《PNAS》，《Scientific Reports》，《Toxicological Sciences》，《J Chem Inf Model》，《European Journal of Medicinal Chemistry》等國(guó)際期刊上發(fā)表發(fā)表SCI收錄論文60余篇，單篇最高引用90余次，累計(jì)引用310余次。申請(qǐng)發(fā)明專(zhuān)利5項(xiàng)，獲權(quán)2項(xiàng)。先后主持國(guó)家高技術(shù)發(fā)展研究計(jì)劃（“863”計(jì)劃）、國(guó)家自然科學(xué)基金等多項(xiàng)省部級(jí)以上科研項(xiàng)目；研究成果“肽定量構(gòu)效關(guān)系研究與應(yīng)用”獲教育部自然科學(xué)獎(jiǎng)二等獎(jiǎng)；曾獲重慶大學(xué)“優(yōu)秀青年教師”和“學(xué)生科技園丁”等榮譽(yù)稱(chēng)號(hào)。指導(dǎo)本科生參加美國(guó)數(shù)學(xué)建模競(jìng)賽獲二等獎(jiǎng)和三等獎(jiǎng)各一項(xiàng)；指導(dǎo)研究生獲得重慶市優(yōu)秀博士學(xué)位論文1人，重慶市優(yōu)秀碩士學(xué)位論文1人，重慶大學(xué)優(yōu)秀畢業(yè)研究生3人�，F(xiàn)為《Journal of Medicinal Chemistry》，《Bioorganic & Medicinal Chemistry Letters》，《SCIENCE IN CHINA》，《CHINESE JOURNAL OF STRUCTURAL CHEMISTRY》等雜志審稿人。

近年來(lái)，主要進(jìn)行基于結(jié)構(gòu)的合理藥物設(shè)計(jì)、遺傳異質(zhì)性藥物毒副作用機(jī)理與個(gè)性化醫(yī)療等相關(guān)研究。歡迎藥學(xué)、生物學(xué)、化學(xué)等相關(guān)專(zhuān)業(yè)學(xué)生報(bào)考本學(xué)科方向研究生。

代表性論文目錄（2010~）：

1. Zhang ZH, Chen S, Mei H, Xuan JK, Guo XQ, Couch L, Dobrovolsky VN, Guo L, Mei N. 2015. Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells.Scientific Reports5

2. Sun JY, Mei H. 2015. QSAR and molecular mechanism analysis of N-substituted oseltamivir derivatives as potent avian influenza H5N1 neuraminidase inhibitors.Chemometrics and Intelligent Laboratory Systems146: 485-93

3. Pan XC, Chao L, Qu SJ, Huang SH, Yang L, Mei H. 2015. An improved large-scale prediction model of CYP1A2 inhibitors by using combined fragment descriptors.Rsc Advances5: 84232-7

4. Liu T, Pan X, Chao L, Tan W, Qu S, Yang L, Wang B, Mei H. 2014. Subangstrom accuracy in pHLA-I modeling by Rosetta FlexPepDock refinement protocol.J Chem Inf Model54: 2233-42

5. Xie JG, Xu ZL, Zhou SB, Pan XC, Cai SX, Yang L, Mei H. 2013. The VHSE-Based Prediction of Proteasomal Cleavage Sites.Plos One8

6. Tan W, Mei H, Chao L, Liu TF, Pan XC, Shu M, Yang L. 2013. Combined QSAR and molecule docking studies on predicting P-glycoprotein inhibitors.Journal of Computer-Aided Molecular Design27: 1067-73

7. Tan QY, Wu JY, Li Y, Mei H, Zhao CJ, Zhang JQ. 2013. A supermolecular curcumin for enhanced antiproliferative and proapoptotic activities: molecular characteristics, computer modeling and in vivo pharmacokinetics.Nanotechnology24

8. Tan QY, Li Y, Wu JY, Mei H, Zhao CJ, Zhang JQ. 2012. An optimized molecular inclusion complex of diferuloylmethane: enhanced physical properties and biological activity.International Journal of Nanomedicine7: 5385-93

9. Sun J, Mei H. 2012. Docking and 3D-QSAR investigations of pyrrolidine derivatives as potent neuraminidase inhibitors.Chemical Biology & Drug Design79: 863-8

10. Ostrov DA, Grant BJ, Pompeu YA, Sidney J, Harndahl M, Southwood S, Oseroff C, Lu S, Jakoncic J, de Oliveira CAF, Yang L, Mei H, Shi L, Shabanowitz J, English AM, Wriston A, Lucas A, Phillips E, Mallal S, Grey HM, Sette A, Hunt DF, Buus S, Peters B. 2012. Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire.Proceedings of the National Academy of Sciences of the United States of America109: 9959-64

11. Li Y, Mei H, Wu Q, Zhang S, Fang J-L, Shi L, Guo L. 2011. Methysticin and 7,8-Dihydromethysticin are Two Major Kavalactones in Kava Extract to Induce CYP1A1.Toxicological Sciences124: 388-99

12. Sun JY, Cai SX, Yan N, Mei H. 2010. Docking and 3D-QSAR studies of influenza neuraminidase inhibitors using three-dimensional holographic vector of atomic interaction field analysis.European Journal of Medicinal Chemistry45: 1008-14

13. Sun JY, Cai SX, Mei H, Li JA, Yan N, Wang Q, Lin ZH, Huo DQ. 2010. Molecular Docking and QSAR Studies on Substituted Acyl(thio)urea and Thiadiazolo [2,3-alpha] Pyrimidine Derivatives as Potent Inhibitors of Influenza Virus Neuraminidase.Chemical Biology & Drug Design76: 245-54