清華大學(xué)

研究領(lǐng)域從毒理學(xué)的角度研究環(huán)境污染物與人類健康之間的關(guān)系。包括以基因組技術(shù)為基礎(chǔ)的新的毒性檢測和預(yù)測方法研究，以分子生物學(xué)和細(xì)胞生物學(xué)為基礎(chǔ)的毒性機(jī)理研究，新興有毒污染物的篩選，污染物健康基準(zhǔn)和標(biāo)準(zhǔn)的研究等。？

研究概況

實驗室致力于解決三大問題：什么污染物是對健康有害的？這些污染物為什么有害？環(huán)境中多大量的污染物才對健康有害？主持和參與的項目有：

1. 國家科技重大專項項目《水體污染控制與治理科技重大專項》下子課題《再生水親水景觀微量靶污染物檢測與防控技術(shù)體系》，2017ZX07103-004，2017.1-2020.6，主要參與人，負(fù)責(zé)部分137.28萬。

2. 國家自然科學(xué)基金面上項目《城市雜用再生水吸入暴露風(fēng)險因子研究》，No. 21777084，2018.1-2021.12，65萬，項目負(fù)責(zé)人。

3. 國家重點研發(fā)計劃項目，政府間國際科技創(chuàng)新合作重點專項《再生水安全供水系統(tǒng)與關(guān)鍵技術(shù)》，2016YFE0118800，2016.12-2019.12，1675萬，主要參與人，負(fù)責(zé)部分110萬。

4. 國家重點研發(fā)計劃項目《京津冀水資源安全保障技術(shù)研發(fā)集成與示范應(yīng)用》下課題《京津冀非常規(guī)水安全利用技術(shù)研發(fā)示范》，2016YFC0401405，2016.7-2020.12，負(fù)責(zé)部分55萬，主要參與人。

5. 國家自然科學(xué)基金面上項目《再生水中新興雌激素活性消毒副產(chǎn)物的親和分離鑒定及其生成規(guī)律的研究》，NO. 21377066, 2014.1-2017.12，82萬，項目負(fù)責(zé)人。

6. 國家高技術(shù)研究發(fā)展計劃(863計劃)《再生水的安全性評價與控制技術(shù)》，NO. 2013AA065205, 2013.1-2015.12，負(fù)責(zé)部分60萬，主要參與人。

7. 清華大學(xué)自主科研青年教師自主選題基礎(chǔ)研究項目，《基于雌激素受體致病機(jī)理的污染物篩選與鑒定》，2011.7-2014.6，62萬，項目負(fù)責(zé)人。

8. 環(huán)保部水專項（與中國環(huán)境科學(xué)研究院合作），《重點流域優(yōu)控污染物水環(huán)境質(zhì)量基準(zhǔn)研究》，2012.1-2015.12，負(fù)責(zé)部分16萬，參與人。

9. 國家自然科學(xué)基金青年科學(xué)基金項目《MicroRNA毒理基因組學(xué)：雌激素在小鼠體內(nèi)標(biāo)準(zhǔn)圖譜的研究》，2011.1-2013.12，21007030, 20萬，項目負(fù)責(zé)人。

10. 教育部留學(xué)回國啟動基金，《MicroRNA毒理基因組學(xué)標(biāo)準(zhǔn)圖譜的研究》，2012.1-2012.12，5萬，項目負(fù)責(zé)人。

11. 日本松下公司合作項目，《堿性加氫飲用水胃保護(hù)功能研究》，2012.3-2012.12，30萬，項目負(fù)責(zé)人。

獎勵與榮譽

2017年，JSWE-IDEA Water Environment International Exchange Award.

2016年，中國環(huán)境科學(xué)學(xué)會第十一屆“優(yōu)秀環(huán)境科技工作者獎”

2015年，寶鋼優(yōu)秀教師獎

2014年，環(huán)保部“國家環(huán)境保護(hù)專業(yè)技術(shù)青年拔尖人才”稱號

2010年，中國環(huán)境科學(xué)學(xué)會第七屆“青年科技獎”

2002年，教育部提名國家科學(xué)技術(shù)一等獎，第三完成人？

學(xué)術(shù)成果部分論文：

[1] Xu B, Li K, Qiao J, Liungai Z, Chen C*, Lu Y*. UV photoconversion of environmental oestrogen diethylstilbestrol and its persistence in surface water under sunlight. Water Research, 2017, 127:77-85.

[2] Li GQ; Wang WL; Huo ZY; Lu Y*; Hu HY*. Comparison of UV-LED and low pressure UV for water disinfection: photoreactivation and dark repair of Escherichia coli. Water Research, 2017, 126:134-143.

[3] Lv XT, Zhang X, Du Ye, Wu QY*, Lu Y*, Hu HY. Solar light irradiation significantly reduced cytotoxicity and disinfection byproducts in chlorinated reclaimed water. Water Research, 2017, 126:162-169.

[4] Li GQ, Yu T, Wu QY, Lu Y*, Hu HY*. Development of an ATP luminescence-based method for assimilable organic carbon determination in reclaimed water. Water Research, 2017, 123:345-352.

[5] Liu L, Zhou X*, Lu Y*, Shan D, Xu B, He M, Shi H, Qian Y. Facile screening of potential xenoestrogens by an estrogen receptor-based reusable optical biosensor. Biosensors and Bioelectronics, 2017, 97:16-20.

[6] Yu T, Meng L, Zhao Q-B, Shi Ye, Hu H-Y, Lu Y*. Effects of chemical cleaning on RO membrane inorganic, organic and microbial foulant removal in a full-scale plant for municipal wastewater reclamation. Water Research, 2017, 113:1-10.

[7] Xue J, Zhang J, Xu B, Xie J, Wu W, Lu Y*. Endotoxins: the critical risk factor in reclaimed water via inhalation exposure. Environmental Science & Technology, 2016, 50:11957-11964.

[8] Duan R, Lu Y*, Hou L, Du L, Sun L, Tang X. The U-shaped microRNA expression pattern could be a new concept biomarker for environmental estrogen. Frontiers of Environmental Science & Engineering, 2016, 10(6):11.

[9] Li M, Xu B, Liungai Z, Hu H-Y, Qiao J*, Lu Y*. The removal of estrogenic activity with UV/chlorine technology and identification of novel estrogenic disinfection by-products. Journal of Hazardous Materials, 2016, 307:119-126..

[10] Yu T, Li GQ, Lin WQ, Hu H-Y, Lu Y*. Coagulation increased the growth potential of various species bacteria of the effluent of a MBR for the treatment of domestic wastewater. Environmental Science and Pollution Research, 2017, 24(6):5126-5133.

[11] Zhang J, Xue J, Xu B, Xie J, Qiao J*, Lu Y*. Inhibition of Lipopolysaccharide Induced Acute Inflammation in Lung by Chlorination. Journal of Hazardous Materials, 2016, 303:131-136.

[12] Yang Y, Lu Y*, Wu QY, Hu H-Y*, Chen YH, Liu WL. Evidence of ATP assay as an appropriate alternative of MTT assay for cytotoxicity of secondary effluents from WWTPs. Ecotoxicology and Environmental Safety, 2015, 122:490-496.

[13] Xue J, Shang G, Tanaka Y, Saihara Y, Hou L, Velasquez N, Liu W, Lu Y*. Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water, BMC Complementary and Alternative Medicine, 2014, 14:81.

[14] Shang G, Xue J, Li M, Hu HY, Lu Y*. Isolation and identification of novel estrogenic chlorination by-products of diethylstilbestrol by recombinant estrogen receptor α immobilized affinity chromatography. Chemosphere, 2014, 104:251-257.

[15] Hou LY, Lu Y*, Li Y, Li L. MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus. Frontiers of Environmental Science and Engineering, 2014, 8(1):99-105.

[16] Xue JL, Lu Y*, Velasquez N, Yu RZ, Hu HY, Liu ZT, Meng W. Introduction of risk size in the determination of uncertainty factor UFL in risk assessment. Environmental Research Letters, 2012, 7(3):034036.

[17] Xu, X; Rock, JR; Lu, Y; Futtner, C; Schwab, B; Guinney, J; Hogan, BLM; Onaitis, MW*. Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma. PNAS, 2012, 109(13): 4910-4915.

[18] Lu Y*, Hou LY，Hu HY, Li L. Progress in toxicogenomics. Ecology and Environmental Sciences, 2010, 19(9):2232-2239.

[19] Lu Y, Futtner C, Rock JR, Xu X, Whitworth W, Hogan BLM, Onaitis MW*. Evidence That SOX2 Overexpression Is Oncogenic in the Lung. Plos One 2010;5(6).

[20] Rock JR, Onaitis MW, Rawlins EL, Lu Y, Clark CP, Xue Y, Randell SH, Hogan BLM*. Basal cells as stem cells of the mouse trachea and human airway epithelium. Proceedings of the National Academy of Sciences of the United States of America 2009;106:12771-12775.

[21] Erhunmwunsee L, Lu Y, Luo XY, Harpole DH, Hogan BLM, Onaitis MW*. Basal cells in lung cancer. Journal of the American College of Surgeons 2008;207:S30-S30.

[22] Lu Y, Thomson JM, Wong HYF, Hammond SM, Hogan BLM*. Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Developmental Biology 2007;310:442-453.

專利：

陸韻，商國棟，李曼，《分離檢測環(huán)境中雌激素類內(nèi)分泌干擾物的方法》，申請?zhí)?01310677352.6。