北京理工大學(xué)

月～2008 年 7 月：浙江大學(xué)材料與化工學(xué)院化學(xué)工程與技術(shù)流動(dòng)站博士后；2008 年 8 月：北京理工大學(xué)生命學(xué)院生物工程系講師；2010 年 9 月：北京理工大學(xué)生命學(xué)院生物工程系副教授；2017 年 12 月至今：北京理工大學(xué)化學(xué)與化工學(xué)院生化工程系副教授。主要從事生物催化與轉(zhuǎn)化、酶工程、發(fā)酵工程等方面的研究工作，在手性藥物的生物拆分與不對(duì)稱合成、醫(yī)藥中間體及生物基化工品生物合成領(lǐng)域的研究工作具有一定特色。近年來探討利用組合生物催化與轉(zhuǎn)化手段，構(gòu)建高效無細(xì)胞生物合成系統(tǒng)，探索相關(guān)平臺(tái)化合物和藥物中間體的生物轉(zhuǎn)化與合成規(guī)律。近年來發(fā)表學(xué)術(shù)論文 20 余篇，主持完成了中國(guó)博士后科學(xué)基金、國(guó)家高技術(shù)研究發(fā)展計(jì)劃（863 計(jì)劃）、國(guó)家自然科學(xué)基金（面上）等多項(xiàng)基金資助項(xiàng)目與橫向合作課題的研究工作。

A）近年來已主持完成的部分項(xiàng)目

[1]中國(guó)博士后科學(xué)基金項(xiàng)目（項(xiàng)目編號(hào)：20060401045）：立體選擇性脂肪酶拆分手性藥物中的關(guān)鍵技術(shù)研究；第一負(fù)責(zé)人，全面負(fù)責(zé)項(xiàng)目實(shí)施。

[2]國(guó)家高技術(shù)研究發(fā)展計(jì)劃（863 計(jì)劃）重點(diǎn)項(xiàng)目（項(xiàng)目編號(hào)：2009AA02Z202）：全酶法清潔生產(chǎn)木糖醇關(guān)鍵技術(shù)研究；子課題第一負(fù)責(zé)人，主要負(fù)責(zé)木糖代謝途徑的改造。

[3]北京理工大學(xué)優(yōu)秀青年教師資助計(jì)劃項(xiàng)目（項(xiàng)目編號(hào)：2009Y1118）：對(duì)映體選擇性微

生物脂肪酶動(dòng)力學(xué)拆分手性藥物及中間體的應(yīng)用基礎(chǔ)研究；第一負(fù)責(zé)人，全面負(fù)責(zé)項(xiàng)目實(shí)

施。

[4]國(guó)家自然科學(xué)基金（面上）項(xiàng)目（項(xiàng)目編號(hào)：21276025）：熒光假單胞桿菌磷脂酶 B

界面催化識(shí)別機(jī)制及其定向調(diào)控規(guī)律研究；第一負(fù)責(zé)人，全面負(fù)責(zé)項(xiàng)目實(shí)施。

B）近年來已發(fā)表的部分論文

[1]DZ Dai, LM Xia, et al. Enhanced production of Penicillium expansum PED-03 lipase through the control of culture conditions and the application of the crude enzyme in kinetic resolution of racemic allethrolone. Biotech Prog, 2005, 21(4): 1165-1168.

[2]DZ Dai, LM Xia, et al. Resolution of (R, S)-2-octanol by Penicillium expansum PED-03 lipase immobilized on modified ultrastable-Y molecular sieve in microaqueous media. Process Biochem, 2006, 41: 1455~1460.

[3]DZ Dai, LM Xia, et al. Effect of lipase immobilization on the resolution of (R, S)-2-octanol in nonaqueous media using modified ultrastable-Y molecular sieve as support. App Biochem Biotech, 2006, 134(1): 39-50.

[4]DZ Dai, LM Xia, et al. Enzymatic resolution of (R, S)-2-octanol by Ultrastable-Y molecular sieve immobilized-lipase in microaqueous media. Chem J Chin Univ, 2007, 28(12): 2307-2310.
[5]DZ Dai, LM Xia, et al. Production of the lipase from Penicillium expansum PED-03 and its application in the resolution of racemic allethrolone. J Chem Eng Chin Univ, 2008, 22(1): 166-171.

[6]DZ Dai, LM Xia, et al. Effect of immobilization by modified ultrastable-Y molecular sieve on the resolution of (R, S)-2-octanol in nonaqueous media by lipase. Acta chimica sinica, 2008, 66(2): 245-250.

[7]SP Zou, DZ Dai, LM Li, et al. Biosynthesis of glycyrrhetinic acid monoglucuronide by whole-cell of Penicillium purpurogenum in an aqueous/organic system. CIESC J, 2009, 60(8): 2040~2045.

[8]L Xiang, F Qi, DZ Dai, et al. Simulated microgravity affects growth of Escherichia coli and recombinant β-D-glucuronidase production. Appl Biochem Biotechnol, 2010, 162(3): 654-61.

[9]DM He, Imdad Kaleem, DZ Dai, et al. Biosynthesis of glycyrrhetic acid 3-O-mono- β-D-glucuronide catalyzed by β-D-glucuronidase with enhanced bond selectivity in an ionic liquid/buffer biphasic system. Prcess biochem, 2010, 45(12): 1916-1922.

[10]FY Jiang, JM Wang, DZ Dai, et al. Degumming of vegetable oils by a novel phospholipase B from Pseudomonas fluorescens BIT-18. Bioresource Technol, 2011, 102(17): 8052-8056.

[11]FY Jiang, JM Wang, DZ Dai, et al. Optimization of degumming process for soybean oil by phospholipase B. J Chem Technol Biotechnol, 2011, 86(8): 1081-1087.

[12]F Qi, DZ Dai, C Li, et al. Effects of Low-Shear Modeled Microgravity on the Characterization of Recombinant beta-D-Glucuronidase Expressed in Pichia pastoris. Appl Biochem Biotechnol, 2011, 163(1): 162-172.

[13]FY Jiang, JM Wang, DZ Dai, et al. Screening and identification of phospholipase-producing strains and their applications. CIESC J, 2012, 63(3): 887-893.
[14]XX Guo, C Li, DZ Dai, et al.A novel pathway construction in Candida tropicalis for direct xylitol conversion from corncob xylan. Bioresour Technol,2012,128C:547-552.