中國藥科大學

孔毅,男，1968年4月出生，博士，中國藥科大學副教授，碩士研究生導師。

2001年獲中國藥科大學博士學位，2003年在南京大學與江蘇萬邦生化醫(yī)藥股份有限公司從事博士后研究工作。2010年5月-9月，英國帝國理工學院訪問學者；2012年10月-2013年11月，北卡羅萊納大學訪問學者。江蘇省青藍工程中青年學科帶頭人培養(yǎng)對象。

研究方向

1微生物藥物和生化與生物技術藥物的開發(fā)與應用
2天然生化活性物質(zhì)及其功能基因的研究
探尋自然界中結(jié)構新穎、生理活性強的天然多肽，并研究其結(jié)構與功能的關系，為創(chuàng)新藥物研發(fā)服務。

主要研究技術包括:蛋白質(zhì)及多肽的分離純化，多肽的結(jié)構分析，酶法及ELISA法活性篩選，體內(nèi)外抗血栓活性及分子作用機制研究，計算機輔助藥物設計等。

發(fā)明專利：

申請發(fā)明專利10余件，其中授權專利5件。

科研項目：

主持國家自然科學基金1項,省級課題2項,美國強生制藥課題1項,企業(yè)課題6項.參與國家自然科學基金2項,重大新藥創(chuàng)制1項。

近五年發(fā)表論文(第一或通訊作者)

2015
Mei-Mei Chen, Xiao-Hui Ye, Xin Ming, Ya-Hui Chen, Ying Wang, Xing-Li Su, Wen Su and Yi Kong. A Novel Direct Factor Xa Inhibitory Peptide with Anti-Platelet Aggregation Activity from Agkistrodon acutus Venom Hydrolysates[J]. Scientific reports, 2015, 5.
Yi Kong, Ying Wang, Wei Yang, Zhou-Ling Xie, Zhi-Yu Li. LX0702, a novel snake venom peptide derivative, inhibits thrombus formation via affecting the binding of fibrinogen with GPIIb/IIIa[J]. Journal of pharmacological sciences, 2015, 127(4): 462-466.
Xing-Li Su, Wen Su, Zhi-Long He, Xin Ming and Yi Kong. Tripeptide SQL Inhibits Platelet Aggregation and Thrombus Formation via Affecting PI3K/Akt Signaling[J]. Journal of cardiovascular pharmacology, 2015.
Xiao-Hui Ye, Mei-Mei Chen, Ya-Hui Chen, Xing-Li Su, Ying Wang, Wen Su, Yi Kong. Isolation and Characterization of a Novel Antithrombotic Peptide from Enzymatic Hydrolysate of Agkistrodon acutus Venom[J]. International Journal of Peptide Research and Therapeutics, 1-9.
Guangyan Cheng, Liying He, Zhibin Sun, Zhongli Cui, Yingxiang Du, Yi Kong. Purification and biochemical characterization of a novel fibrinolytic enzyme from Streptomyces sp. P3[J]. Journal of microbiology and biotechnology, 2015.
 
2014
Yi Kong, Cheng Xu, Zhi-Long He, Qiu-Mei Zhou, Jin-Bin Wang, Zhi-Yu Li, Xin Ming. A novel peptide inhibitor of platelet aggregation from stiff silkworm, Bombyx batryticatus[J]. Peptides, 2014, 53: 70-78.
Yi Kong, Shuai Li, Yu Shao, Zhi-Long He, Mei-Mei Chen, Xin Ming, Ji-Fu Wei. Antithrombotic Peptides from Scolopendra subspinipes mutilans Hydrolysates[J]. International Journal of Peptide Research and Therapeutics, 2014, 20(2): 245-252.
Yi Kong, Hao Chen, Yong-Qing Wang, Ling Meng and Ji-Fu Wei. Direct thrombin inhibitors: Patents 2002-2012 (Review)[J]. Molecular medicine reports, 2014, 9(5): 1506-1514.
Hao Chen, Min Jin, Yi-Fen Wang, Yong-Qing Wang, Ling Meng, Rong Li, Jia-Ping Wang, Li Gao, Yi Kong and Ji-Fu Wei. Effect of Toona microcarpa Harms Leaf Extract on the Coagulation System[J]. BioMed research international, 2014
 
2013
Yi Kong, Yu Shao, Hao Chen, Xin Ming, Jin-Bin Wang, Zhi-Yu Li, Ji-Fu Wei. A novel factor Xa-inhibiting peptide from centipedes venom[J]. International journal of peptide research and therapeutics, 2013, 19(4): 303-311.
Yi Kong, Jing Hui, Yu Shao, Shi-Long Huang, Hao Chen and Ji-Fu Wei. Cytotoxic and anticoagulant peptide from Scolopendra subspinipes mutilans venom[J]. African J Pharm Pharmacol, 2013, 7: 2238-2245.
Yi Kong, Shi-Long Huang, Yu Shao, Shuai Li, Ji-Fu Wei. Purification and characterization of a novel antithrombotic peptide from Scolopendra subspinipes mutilans[J]. Journal of ethnopharmacology, 2013, 145(1): 182-186.
 
2012
Jing Xiong, Li Bai, Wei Fang, Jianyang Fu, Weirong Fang, Juan Cen, Yi Kong, Yunman Li. New peptide pENW (pGlu-Asn-Trp) inhibits platelet activation by attenuating Akt phosphorylation[J]. European Journal of Pharmaceutical Sciences, 2012, 45(5): 552-558.
 
2011
Hongwen Zhao, Yi Kong, Hanjin Wang, Tianhua Yan, Feifei Feng, Jianmin Bian, Yan Yang and Haining Yu. A defensin‐like antimicrobial peptide from the venoms of spider, Ornithoctonus hainana[J]. Journal of Peptide Science, 2011, 17(7): 540-544.

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