中國(guó)藥科大學(xué)

具有全面、規(guī)范的中藥新藥審評(píng)培訓(xùn)經(jīng)歷，系統(tǒng)、現(xiàn)代的中藥研究經(jīng)歷和豐富的中、西藥生產(chǎn)研發(fā)經(jīng)驗(yàn)。將共晶、液晶、納晶等新技術(shù)引入到藥物研發(fā)領(lǐng)域，取得突破性成果；在口腔粘膜給藥系統(tǒng)、緩控釋給藥系統(tǒng)、微粒給藥系統(tǒng)等形成特色的研究方向；在抗腫瘤、心腦血管、抗感染、中樞神經(jīng)系統(tǒng)等領(lǐng)域研發(fā)方向明確。

應(yīng)用產(chǎn)業(yè)化成熟度高。申請(qǐng)專(zhuān)利12項(xiàng)，獲得授權(quán)專(zhuān)利6項(xiàng)；與國(guó)內(nèi)外企業(yè)簽訂新制劑與新給藥系統(tǒng)合作開(kāi)發(fā)協(xié)議近20項(xiàng)，目前已有13項(xiàng)均已通過(guò)了企業(yè)生產(chǎn)線工藝驗(yàn)證，產(chǎn)業(yè)化成果顯著。

注重制劑的基礎(chǔ)理論研究，為211引進(jìn)人才；2010年獲得江蘇省“六大人才高峰”計(jì)劃（A類(lèi)）；目前獲得國(guó)家、省部級(jí)等各類(lèi)基金10余項(xiàng)；發(fā)表SCI論文20余篇；擔(dān)任國(guó)際期刊AAPS Pharma Sci Tech，International Journal of Pharmaceutics審稿專(zhuān)家。

主要研究方向：

1）藥物制劑新劑型與新技術(shù)研究

2）微粒給藥系統(tǒng)的研究

3）中藥與輔料相互關(guān)系的研究

4）天然藥物的研發(fā)與評(píng)價(jià)

代表性論文：

Physicochemical and pharmacokinetic characterization of a spray-dried malotilate emulsion. Int J Pharm, 2011, 414(1-2):186-192.

Preparation and evaluation of glyceryl monooleate-coated hollow-bioadhesive microspheres for gastroretentive drug delivery. Int J Pharm, 2011, 413(1-2):103-109.

Physicochemical and pharmacokinetic characterization of a spray-dried cefpodoxime proxetil nanosuspension. Chem Pharm Bull 2010, 58(7): 912-917.

Interaction characteristics with bovine serum albumin and retarded nitric oxide release of ZCVI(4)-2, a new nitric oxide-releasing derivative of oleanolic acid. Chem Pharm Bull. 2011, 59(6): 734-741.

Enhanced dissolution and stability of adefovir dipivoxil by cocrystal formation. J Pharm Pharmacol, 2011, 63(4): 483–490.

Formation thermodynamics of adefovir dipivoxil-saccharin co-crystals. Acta Phys Chim Sin, 2011, 27(3): 547-552.

Pharmaceutical cocrystals. Prog Chem, 2010,22(5): 829-836.

Optimization of preparation and property studies on glycosylated albumin as drug carrier for nanoparticles. Pharmazie, 2011, 66(7): 484-490.

Albumin as drug carriers. Prog Chem, 2011, 23(8): 168-176.

10. Effect of poloxamer F 127 and paeonol on GMO-based liquid crystal transformation. Acta Chim Sin, 2011, 69(13): 1503-1508.

Enhanced bioavailability after oral and pulmonary administration of baicalein nanocrystal. Int J Pharm. 2011, 420(1):180-188.

Spray-dried oil-in-water emulsion to improve the intestinal absorption and oral bioavailability of ZLR-8, a nitric oxide-releasing derivative of diclofenac. J Pharm Pharmacol, 2011, 63(12):1531-1538.

Physicochemical characterization and an injection formulation study of water insoluble ZCVI4-2，a novel NO-donor anti-cancer compound. Arch Pharm Res, 2012, 35(7): 1177-1186.

Biopharmaceutics classification and intestinal absorption study of apigenin. Int J Pharm, 2012, 436(1-2): 311-317.

Coformer selection based on degradation pathway of drugs: a case study of adefovir dipivoxil-saccharin and adefovir dipivoxil-nicotinamide cocrystals. Int J Pharm, 2012, 438(1-2): 327-335

Comparative pharmacokinetic study of chlorogenic acid after oral administration of lonicerae japonicae flos and shuang-huang-lian in normal and febrile rats. Phytother Res, 2014, 28(1):144-147.

Simultaneous determination of four alkaloids in mice plasma and brain by LC-MS/MS for pharmacokinetic studies after administration of Corydalis Rhizoma and Yuanhu Zhitong extracts. J Pharm Biomed Anal, 2014, 92:6-12.

專(zhuān)著：

1）高緣（主編）.國(guó)家執(zhí)業(yè)藥師資格考試中藥學(xué)專(zhuān)業(yè)知識(shí)（一）.中國(guó)協(xié)和醫(yī)科大學(xué)出版社

2）高緣（副主編）.現(xiàn)代中藥制劑新技術(shù).江蘇科學(xué)技術(shù)出版社

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