中國藥科大學

譚寧華，女，1963年10月生，博士、教授、博士生導師。

研究方向：天然藥物化學（中藥化學）。

簡介：2015年5月作為高層次人才從中國科學院昆明植物研究所引進到中國藥科大學，現(xiàn)任中國藥科大學中藥學院副院長。國家杰出青年基金獲得者，享受國務院政府特殊津貼，中國科學院“百人計劃”和王寬誠西部學者突出貢獻獎獲得者，云南省中青年學術帶頭人和“三八”紅旗手。中國植物學會理事及其植物化學和資源學專業(yè)委員會主任委員，中國化學會化學生物學專業(yè)委員會和女化學工作者委員會委員，世界中醫(yī)藥學會聯(lián)合會中藥分析專業(yè)委員會和中藥化學專業(yè)委員會委員。在國內外學術會議上作邀請報告70多次，主辦大型國內或國際學術會議4次，Chemical Reviews、《中國天然藥物》等30多種國內外雜志審稿人或編委，國家、云南省、中科院等項目評審專家。培養(yǎng)及聯(lián)合培養(yǎng)的研究生和博士后80余名，包括美國、澳大利亞、香港、尼日利亞、喀麥隆的國外研究生和博士后12名，與國內外20多個實驗室建立了廣泛友好的實質性合作關系。

學習工作經(jīng)歷：1984年學士畢業(yè)于貴陽醫(yī)學院藥學系，1990年碩士畢業(yè)于中國藥科大學天然藥物化學專業(yè)，1993年博士畢業(yè)于中國藥科大學天然藥物化學專業(yè)。1984-1987年貴陽醫(yī)學院藥學系教師，1993-1995年中國科學院昆明植物研究所植物化學博士后，1996-2015年中國科學院昆明植物研究所植物化學與西部植物資源持續(xù)利用國家重點實驗室研究組長、副研究員和研究員，2015年至今中國藥科大學教授。1996、1998、2006、2008年先后到德國BAYER藥物研究所、美國NCI、澳大利亞昆士蘭大學和美國威斯康星大學從事合作研究。

研究領域：主要從事天然藥物化學（中藥化學）研究，特別是植物環(huán)肽的資源、化學、生物學、化學生物學和新藥研究，目前主要集中在含環(huán)肽藥典中藥物質基礎及功效成分、抗腫瘤和免疫抑制新藥研究、止咳中藥。研究工作涉及天然藥物化學（中藥化學）、藥用植物資源、藥物篩選與作用機制、藥物設計與有機合作、化學生物學、新藥研發(fā)等。

研究成果：在Chemical Reviews, Science, Organic Letters, British Journal of Pharmacology, Journal of Natural Products, Phytochemistry等國內外雜志上發(fā)表論文270多篇，其中SCI論文160多篇，參編專著章節(jié)10個，申請或授權專利16項，獲得云南省自然科學一等獎1項。先后承擔國家自然科學基金、973、新藥創(chuàng)制重大專項、中科院項目、云南省自然科學基金、國際合作等項目40多個。代表性工作是植物環(huán)肽、復雜配糖體和抗腫瘤活性研究等。在植物環(huán)肽研究方面取得了系統(tǒng)的創(chuàng)新性研究成果，獲得2006年度云南省自然科學一等獎，應邀在化學學科影響因子第一的ChemicalReviews（2006,106:840）發(fā)表論文，該文入選2008年度首屆中國百篇最具影響優(yōu)秀國際學術論文。

電子郵箱：nhtan@mail.kib.ac.cn。

近十年來發(fā)表的代表性學術論文：

1.Clara Bik-San Lau*, Grace Gar-Lee Yue, Kwok-Pui Fung, Ning-Hua Tan, Ping-Chung Leung. The potential roles of Chinese herbal medicines in cancer management. Science, 2015, 347 (6219 suppl): S45-S47
2.Hoi-Wing Leung, Zhe Wang, Grace Gar-Lee Yue, Si-Meng Zhao, Julia Kin-Ming Lee, Kwok-Pui Fung, Ping-Chung Leung, Clara Bik-San Lau*, Ning-Hua Tan*. Cyclopeptide RA-V inhibits cell adhesion and invasion in both estrogen receptor positive and negative breast cancer cells probably via PI3K/AKT and NF-kBsignaling pathways. BBA Molecular Cell Research, 2015, 1853: 1827-1840
3.Zeng-Ying Qiao,Di Zhang,Chun-Yuan Hou, Si-Meng Zhao,Ya Liu, Yu-Juan Gao, Ning-Hua Tan, * Hao Wang*. A PH-responsive natural cyclopeptide RA-V drug formulation for improved breast cancer therapy. Journal of Materials Chemistry B, 2015, 3: 4514-4523
4.Na-Na Liu, Si-Meng Zhao, Jing-Feng Zhao, Guang-Zhi Zeng, Ning-Hua Tan*, Jian-Ping Liu*. Synthesis and conformation studies of rubiyunnanin B analogs. Tetrahedron, 2014, 70(37): 6630-6640
5.Mao-Bo Huang, Si-Meng Zhao, Guang-Zhi Zeng*, Bin Kuang, Xiao-Qiang Chen, Ning-Hua Tan*. Rubischumanins A-C, three cytotoxic cyclopeptides from Rubia schumanniana. Tetrahedron, 2014, 70: 7627-7631
6.Si-Meng Zhao, Zhe Wang, Guang-Zhi Zeng*, Wei-Wu Song, Xiao-Qiang Chen, Ning-Hua Tan*. Novel cytotoxic naphthohydroquinone dimers from Rubia alata. Organic Letters, 2014, 16: 5576-5579
7.Wen-Yan Xu, Bo Wang, Yuan Lin*, Yu-Hua Li, Zhao-Hui Su, Wen-Jun He, Ning-Hua Tan*, Qian Wang. Emulsion stabilized by mini cyclic proteins for bioactive compounds delivery. RSC Advances, 2014, 4: 48000-48003
8.Lai Yue Chan, Wen-Jun He, Ning-Hua Tan*, Guang-Zhi Zeng, David J. Craik, Norelle L. Daly*. A new family of cystine knot peptides from the seeds of Momordica cochinchinensis. Peptides, 2013, 39: 29-35
9.Grace G.L. Yue, Ben C.L. Chan, Hin-Fai Kwok, Yuk-Lau Wong, Hoi-Wing Leung， Chang-Jiu Ji, Kwok-Pui Fung, Ping-Chung Leung, Ning-Hua Tan*, Clara B.S. Lau*. Anti-angiogenesis and immunomodulatory activities of an anti-tumor sesquiterpene bigelovin isolated from Inula helianthus-aquatica. European Journal of Medicinal Chemistry, 2013, 59: 243-252
10.Xian-Ying Fang, Wei Chen, Jun-Ting Fan, Ran Song, Lu Wang, Yan-Hong Gu, Guang-Zhi Zeng, Yan Shen, Xue-Feng Wu, Ning-Hua Tan*, Yang Sun*, Qiang Xu*. Plant cyclopeptide RA-V kills human breast cancer cells by inducing mitochondria-mediated apoptosis through blocking PDK1-AKT interaction. Toxicology and Applied Pharmacology, 2013, 267: 95-103
11.Hui-Min Xu, Hua Yi, Wen-Bing Zhou, Wen-Jun He,Guang-Zhi Zeng, Wen-Yan Xu, Ning-Hua Tan*. Tataricins A-B, two novel cyclotetrapeptides from Aster tataricus, and their absolute configuration assignment. Tetrahedron Letters, 2013, 54: 1380-1383
12.Hui-Min Xu, Guang-Zhi Zeng, Wen-Bing Zhou, Wen-Jun He, Ning-Hua Tan*. Astins K-P, six new chlorinated cyclopentapeptides from Aster tataricus. Tetrahedron, 2013, 69: 7964-7969
13.Wen-Jun He, Lai Yue Chan, Richard J. Clark, Jun Tang, Guang-Zhi Zeng, Octavio L. Franco, Cinzia Cantacessi, David J. Craik, Norelle L. Daly*, Ning-Hua Tan*. Novel inhibitor cyctine knot peptides from Momordica charantia. PLOS ONE, 2013, 8(10): e75334
14.Wen-Jun He, Zhao-Hui Fu, Guang-Zhi Zeng, Yu-Mei Zhang*, Hong-Jing Han, He Yan, Chang-Jiu Ji, Hong-Biao Chu, Ning-Hua Tan*. Terpene and lignan glycosides from the twigs and leaves of an endangered conifer, Cathaya argyrophylla. Phytochemistry, 2012, 83：63-69
15.Wen-Yan Xu, Hong-Tao Zhu, Ning-Hua Tan*, Jun Tang, Ying-Jun Zhang, Ron L. Cerny, Liangcheng Du*. Biosynthetic studies of plant cyclopeptide heterophyllin B from the Chinese medicinal plant Pseudostellaria heterophylla. Plant Cell, Tissue & Organ Culture, 2012, 108: 137-14
16.Jun-Ju Xu, Chang-Jiu Ji, Yu-Mei Zhang, Jia Su, Yan Li, Ning-Hua Tan*. Inhibition of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide. Bioorganic & Medicinal Chemistry Letters, 2012, 22: 1660-1663
17.Chang-Jiu Ji, Guang-Zhi Zeng, Jing Han, Wen-Jun He, Yu-Mei Zhang, Ning-Hua Tan*. Zizimauritic acids A-C, three novel nortriterpenes isolated from Ziziphus mauritiana. Bioorganic & Medicinal Chemistry Letters, 2012, 22: 6377-6380
18.Jing Han, Chang-Jiu Ji, Wen-Jun He, Yu Shen, Ying Leng, Wen-Yan Xu, Jun-Ting Fan, Guang-Zhi Zeng, Ling-Dong Kong, Ning-Hua Tan*. Cyclopeptide alkaloids from Ziziphus apetala. Journal of Natural Products, 2011, 74: 2571-2575
19.Jun-Ting Fan, Bin Kuang, Guang-Zhi Zeng, Si-Meng Zhao, Chang-Jiu Ji, Yu-Mei Zhang, Ning-Hua Tan*. Biologically active arborinane-type triterpenoids and anthraquinones from Rubia yunnanensis. Journal of Natural Products, 2011, 74: 2069-2080
20.Grace GL Yue, Jun-Ting Fan, Julia KM Lee, Guang-Zhi Zeng, Tina WF Ho, Kwok-Pui Fung, Ping-Chung Leung, Ning-Hua Tan*, Clara BS Lau*. Cyclopeptide RA-V inhibits angiogenesis by down-regulating ERK1/2 phosphorylation in HUVEC and HMEC-1 endothelial cells. British Journal of Pharmacology, 2011, 164: 1883-1898
21.Yan Shen, Qiong Luo, Hui-Min Xu, Gang-Yuan Gong, Xiao-Bin Zhou, Yang Sun, Xue-Feng Wu, Wen Liu, Guang-Zhi Zeng, Ning-Hua Tan*, Qiang Xu*. Mitochondria-dependent apoptosis of activated T lymphocytes induced by astin C, a plant cyclopeptide, for preventing murine experimental colitis. Biochemical Pharmacology, 2011, 82: 260-268
22.Yi-Shan Chen, Xu-Lin Pan, He Yan, Ning-Hua Tan*. Multiple hydrogen-bonding interactions between macrocyclic triurea and F-, Cl-, Br-, I- and NO3-: A theoretical investigation. Physical Chemistry Chemical Physics, 2011, 13(16): 7384-7395
23.Jun-Ting Fan, Yi-Shan Chen, Wen-Yan Xu, Liangcheng Du, Guang-Zhi Zeng, Yu-Mei Zhang, Jia Su, Yan Li, Ning-Hua Tan*. Rubiyunnanin A and B, two novel cyclic hexapeptides from Rubia yunnanensis. Tetrahedron Letters, 2010, 51: 6810-6813
24.Jun-Ting Fan, Jia Su, Yan-Min Peng, Yan Li, Jia Li, Yu-Bo Zhou, Guang-Zhi Zeng, He Yan, Ning-Hua Tan*. Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kB activation. Bioorganic & Medicinal Chemistry, 2010, 18: 8226-8234
25.Jun Tang, Conan K. Wang, Xu-Lin Pan, He Yan, Guang-Zhi Zeng, Wen-Yan Xu, Wen-Jun He, Norelle L. Daly, David J. Craik*, Ning-Hua Tan*. Isolation and characterization of cytotoxic cyclotides from Viola tricolor. Peptides, 2010, 31: 1434-1440
26.He Yan, Xu-Lin Pan, Ning-Hua Tan*, Jun-Ting Fan, Guang-Zhi Zeng, Hong-Jin Han. 2D- and 3D-QSAR studies on 54 anti-tumor Rubiaceae-type cyclopeptides. European Journal of Medicinal Chemistry, 2009, 44: 3425-3432
27.Wang, C. K., Hu, S. H., Martin, J. L., Sjogren, T., Hajdu, J., Bohlin, L., Claeson, P., Goransson, U., Rosengren, K. J., Tang, J., Tan, N. H., Craik, D. J*. Combined X-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. Journal of Biological Chemistry, 2009, 284(16): 10672-10683
28.Wen-Yan Xu, Jun Tang, Chang-Jiu Ji, Wen-Jun He, Ning-Hua Tan*. Application of a TLC chemical method to detection of cyclotides in plants. Chinese Science Bulletin, 2008, 53(11): 1671-1674
29.Yu-Mei Zhang, Ning-Hua Tan*, Yang Lu, Ying Chang, Rui-Rui Jia. Chamobtusin A, a novel skeleton diterpenoid alkaloid from Chamaecyparis obtusa cv. tetragon. Organic Letters, 2007, 9: 4579-4581
30.Ning-Hua Tan* and Jun Zhou. Plant cyclopeptides. Chemical Reviews, 2006, 106: 840-895