中國(guó)藥科大學(xué)

陳莉，女，教授，博導(dǎo)。1988年本科畢業(yè)于中國(guó)藥科大學(xué)化學(xué)制藥專業(yè)；2004年博士畢業(yè)于中國(guó)藥科大學(xué)藥物化學(xué)專業(yè)。

中國(guó)藥學(xué)會(huì)會(huì)員，九三學(xué)社成員，江蘇省教育廳青藍(lán)工程中青年學(xué)術(shù)帶頭人，2012年4月-2013年4月于美國(guó)伊利諾伊大學(xué)芝加哥校區(qū)（University of Illinois Chicago）從事訪問(wèn)學(xué)者研究。國(guó)家自然科學(xué)基金化學(xué)部同行評(píng)審專家，Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry , Bioorganic & Medicinal Chemistry Letters 等雜志審稿人。主持及參與國(guó)家自然科學(xué)基金面上項(xiàng)目、江蘇省自然科學(xué)基金面上項(xiàng)目、江蘇省青藍(lán)工程中青年學(xué)術(shù)帶頭人培養(yǎng)對(duì)象項(xiàng)目、天津市應(yīng)用基礎(chǔ)及前沿技術(shù)研究計(jì)劃資助項(xiàng)目重點(diǎn)項(xiàng)目及“十一五”重大新藥創(chuàng)制等數(shù)項(xiàng)國(guó)家及省部級(jí)科研項(xiàng)目。在Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry，Bioorganic & Medicinal Chemistry Letters, Chemical Biology & Drug Design, Journal of Asian Natural Products Research, Chinese Chemical Letters, Mini-Reviews in Organic Chemistry等國(guó)內(nèi)外重要刊物發(fā)表學(xué)術(shù)論文數(shù)十篇。

研究方向

01天然產(chǎn)物結(jié)構(gòu)修飾、改造和生物活性研究
02天然藥物與中藥的活性成分研究

主持及參與的基金和人才計(jì)劃項(xiàng)目

1.國(guó)家自然科學(xué)基金面上項(xiàng)目：新型NO/五環(huán)三萜雜合物的分子構(gòu)建及生物活性評(píng)價(jià)（No.2097210，主持）
2.江蘇省自然科學(xué)基金面上項(xiàng)目：基于NO的抗肝癌三萜衍生物分子設(shè)計(jì)及活性相關(guān)性（No.BK2009302，主持）
3.江蘇省青藍(lán)工程中青年學(xué)術(shù)帶頭人培養(yǎng)對(duì)象項(xiàng)目：NO供體型白樺酯酸衍生物的設(shè)計(jì)、合成及生物活性研究（主持）
4.天津市應(yīng)用基礎(chǔ)及前沿技術(shù)研究計(jì)劃資助項(xiàng)目重點(diǎn)項(xiàng)目：新型肝靶向性三萜衍生物的合成及生物活性研究（No.JCZDJC21400，第二）
5.“十一五”重大新藥創(chuàng)制：新型抗血栓和腦缺血候選藥物ZJM-289的研究（參加）

代表性論文(均為通訊作者或第一作者)

1. Li LH, Zhao P, Hu JL, Liu JH, Liu Y, Wang ZQ, Xia YF*, Dai Y, Chen L*. Synthesis, in vitro and in vivo antitumor activity of scopoletin-cinnamic acid hybrids. Eur J Med Chem, 2015, 93: 300-307.
2. Ling Y，Wang ZQ，Wang XM，Li XH，Wang XY，Zhang W，Dai H*，Chen, L*，Zhang YH. Hybrid molecule from FTS-diamine and phenylpropenoic acid as Ras-related signaling inhibitor with potent antitumor activities. Chem Biol Drug Des. 2015; 85: 145–152.
3. Liu JH, Zhu ZF, Tang J, Jiang AQ*, Hu LF, Chen L*. Novel NO-releasing derivatives of betulinic acid with antitumor activity, Chin Chem Lett, 2015, 26: 759-762.
4. Zhao P, Chen L (共同第一), Li LH, Wei ZF, Tong B, Jia YG, Kong LY, Xia YF*, Dai Y*. SC-III3, a novel scopoletin derivative, induces cytotoxicity in hepatocellular cancer cells through oxidative DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation. BMC Cancer, 2014, 14: 987-999.
5.Wang TT, Liu Y, Chen L*. Synthesis and cytotoxic activity of nitric oxide-releasing isosteviol derivatives. Bioorg. Med. Chem. Lett., 2014, 24: 2202-2205.
6. Liu JH, Tang J, Zhu ZF, Chen L*. Design, synthesis, and anti-tumor activity of novel betulinic acid derivatives. J Asian Nat Prod Res, 2014, 1: 34-42.
7. Wang ZQ, Chang RA, Huang HY, Wang XM，Wang XY, Chen L*, Ling Y*. Synthesis and biological evaluation of novel farnesylthiosalicylic acid/salicylic acid hybrids as potential anti-tumor agents. Chin Chem Lett,2014, 25:1545-1549.
8. Luo QF, Liu JH, Chen L*. Recent Advance in Enone and NO-Releasing Derivatives of Oleanolic Acid with Anti-cancer Activity, mini-review in organic chemistry, 2014, 11 (3): 355-361.
9. Chen L, Qiu W, Tang J, Wang ZF, He SY. Synthesis and bioactivity of novel nitric oxide-releasing ursolic acid derivatives. Chin. Chem. Lett., 2011, 22(4), 413-416,
10. Chen L, Zhu ZF, Meng F, Xu CS, Zhang YH. Synthesis and cytotoxicity of oleanolic acid/N-aryl-N-hydroxyguanidine hybrids. Chin J Nat Med, 2010, 8 (6): 436-440.
11. Chen, L.; Zhang, Y.; Kong, X.; Lan, E.; Huang, Z.; Peng, S.; Kaufman, D. L.; Tian, J. Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acid. J Med Chem，2008, 51, 4834-4838.
12. Chen, L.; Zhang, Y.; Kong, X.; Peng, S.; Tian, J. Synthesis and biological evaluation of nitric oxide-releasing derivatives of oleanolic acid as inhibitors of HepG2 cell apoptosis. Bioorg Med Chem Lett , 2007, 17, 2979-2982.

聯(lián)系方式

Tel：13814083082；E-mail：chenliduo12@gmail.comorchenliduo@sohu.com

通訊地址：南京市童家巷24號(hào)，中國(guó)藥科大學(xué)天然藥化教研室，郵編210009