中國(guó)藥科大學(xué)

廖紅，女，博士，教授，博士生和碩士生導(dǎo)師。1987年獲南京大學(xué)生物系理學(xué)學(xué)士學(xué)位，1990年獲南京大學(xué)神經(jīng)化學(xué)理學(xué)碩士學(xué)位，2004年獲中國(guó)藥科大學(xué)藥理學(xué)博士學(xué)位。1990-2002年在南京大學(xué)醫(yī)學(xué)院病理生理學(xué)教研室工作，2005年至今在中國(guó)藥科大學(xué)藥物科學(xué)研究院新藥篩選中心工作，任新藥篩選中心黨支部書記。現(xiàn)為美國(guó)生物化學(xué)和分子生物學(xué)學(xué)會(huì)(ASBMB)會(huì)員，關(guān)注阿爾茨海默病研究與治療的國(guó)際科學(xué)協(xié)會(huì)（ISTAART）會(huì)員，同時(shí)為中國(guó)神經(jīng)科學(xué)會(huì)和中國(guó)藥理學(xué)會(huì)的會(huì)員。2002年8月到新加坡中央醫(yī)院神經(jīng)生物學(xué)研究室作為研究科學(xué)家工作三年。目前與德國(guó)Hamberg大學(xué)、德國(guó)Saarland大學(xué)、澳大利亞Monash大學(xué)、澳大利亞南澳大學(xué)合作開展有關(guān)神經(jīng)退變病的機(jī)制和藥物開發(fā)的研究。主持多項(xiàng)國(guó)家自然科學(xué)基金、江蘇省自然科學(xué)基金、江蘇省的國(guó)際合作項(xiàng)目和江蘇省留學(xué)歸國(guó)人員科技活動(dòng)項(xiàng)目擇優(yōu)資助的等多項(xiàng)基金項(xiàng)目，作為主要參與者參與了“十一五”國(guó)家重大新藥創(chuàng)制等多個(gè)項(xiàng)目。共發(fā)表論文63篇，SCI有32篇。并擁有一項(xiàng)發(fā)明專利證書。

一、專業(yè)研究方向：神經(jīng)藥理學(xué)

二、主要科研工作簡(jiǎn)介

1、具體研究領(lǐng)域：主要從事藥物對(duì)阿爾茨海默病和中風(fēng)的影響及機(jī)理研究；膠質(zhì)細(xì)胞在神經(jīng)損傷與再生中的作用及機(jī)理研究；以及藥物對(duì)神經(jīng)干細(xì)胞增殖和分化的影響及機(jī)理研究。

2、代表性論文（現(xiàn)已表論文63篇左右，其中以第一作者或通訊作者發(fā)表的SCI文章有29篇左右。）

[1].Chen T, Wang J, Li C, Zhang L, An L, Pang T, Shi X, Liao H  Nafamostat mesilate attenuates neuronal damage in a rat model of transient focal cerebral ischemia through thrombin inhibiton. Scientific Reports   2014 Jul 2;4:5531. doi: 10.1038/srep05531.

[2].Liu M, Guo J, Wang J, Zhang L, Pang T, Liao H   Bilobalide induces neuronal differentiation of P19 embryonic carcinoma cells via activating Wnt/β-catenin pathway. Cell Mol Neurobiol   2014; 34(6):913-23

[3].Guo J, Wang J, Liang C, Yan J, Wang Y, Liu G, Jiang Z, Zhang L, Wang X, Wang Y, Zhou X, Liao H. proNGF inhibits proliferation and oligodendrogenesis of postnatal hippocampal neural stem/progenitor cells through p75NTR in vitro. Stem Cell Res. 2013; 11:874-87.

[4].Guo J, Wang J, Zhang Z, Yan J, Chen M, Pang T, Zhang L, Liao H. proNGF inhibits neurogenesis and induces glial activation in adult mouse dentate gyrus. Neurochem Res. 2013;38:1695-703

[5].Chen Y, Sun J, Huang Z, Liao H, Peng S, Lehmann J, Zhang Y. Design, synthesis and evaluation of tacrine-flurbiprofen-nitrate trihybrids as novel anti-Alzheimer's disease agents.Bioorg Med Chem. 2013; 21:2462-70.

[6].Sun J, Fang Y, Chen T, Guo J, Yan J, Song S, Zhang L, Liao H  WIN55, 212-2 promotes differentiation of oligodendrocyte precursor cells and improve remyelination through regulation of the phosphorylation level of the ERK 1/2 via cannabinoid receptor 1 after stroke-induced demyelination; Brain Res. 2013; 1491:225-35.

[7].Sun J, Fang YQ, Ren H, Chen T, Guo JJ, Yan J, Song S, Zhang LY, Liao H  WIN55,212-2 protects oligodendrocyte precursor cells in stroke penumbra following permanent focal cerebral ischemia in rats; Acta Pharmacol Sin. 2013 ;34:119-28.

[8].Fan Y, Sun K, Mao L, Liao H, Wang H  The expression of PGC-1a in the mice brain after traumatic brain injury. Brain Injury.2012; 26:1267–1272

[9].Chen Y, Sun J, Fang L, Liu M, Peng S, Liao H  Lehmann J, Zhang Y. Tacrine−Ferulic Acid−Nitric Oxide (NO) Donor Trihybrids as Potent,Multifunctional Acetyl- and Butyrylcholinesterase Inhibitors. J Med Chem. 2012, 55:4309− 4321

[10].Guo J,Niu R, Huang W, Zhou M, Shi J, Zhang L,Liao H  Growth Factors from Tumor Microenvironment Possibly Promote the Proliferation of Glioblastom a-Derived Stem- like Cells in Vitro. Pathol Oncol Res .2012,18:1047–1057

[11].Yan J, Zhou X, Guo J, Mao L, Wang Y, Sun J, Sun L, Zhang L, Zhou X, Liao H Nogo-66 inhibits adhesion and migration of microglia via GTPase Rho pathway in vitro. J Neurochem.2012,120:721-731

[12].Chen Y, Fang L, Peng S, Liao H, Lehmann J, Zhang Y   Discovery of a novel acetylcholinesterase inhibitor by structure-based virtual screening techniques. Bioorganic & Medicinal Chemistry Letters, 2012,22:3181–3187

[13].Mao L, Wang H, Wang X, Liao H, Zhao X; Transcription Factor Nrf2 Protects the Spinal Cord from Inflammation Produced by Spinal Cord Injury. Journal of Surgical Research,2011,170: e105–e115

[14].Liao H, Sanjaya Mani D; Advances in Oligoprotection. Neuroscience & Medicine , 2011, 2:93-10

[15].Wong I, Liao H, Bai X, Zaknic A, Zhong J, Guan Y, Li Y, Wang Y, Zhou X; ProBDNF inhibits infiltration of ED1+ macrophages after spinal cord injury; Brain, Behavior, and Immunity ,2010,24:585–597

[16].Liao H, Huang W, Niu R, Sun L, Zhang L. Cross-talk between the epidermal growth factor-like repeats/fibronectin 6-8 repeats domains of Tenascin-R and microglia modulates neural stem/progenitor cell proliferation and differentiation.J Neurosci Res. 2008 Jan;86(1):27-34.

[17].Liao H, Huang W, Schachner M, Guan Y, Guo J, Yan J, Qin J, Bai X, Zhang L. beta 1 integrin mediated effects of tenascin-R domains EGFL and FN6-8 on neural stem/progenitor cell  proliferation and differentiation in vitro. J. Biol. Chem. 2008, 283(41): 27927-27936

[18].Liao H, Bu W,  Wang T, Ahmed S, and Xiao ZC   Tenascin-R plays a role in neuroprotection via its distinct domains coordinately modulating the  microglia function.  J. Biol. Chem.  2005:  280(9)：8316-8323  [IF: 5.8]

[19] Tan XW, Liao H, Sun L, Masaru O, Xiao ZC and Dawe XW   Fetal Microchimerism in the Maternal Mouse Brain: A Novel Population of Fetal Progenitor or Stem Cells Able to Cross the Blood-Brain Barrier? Stem Cells,  2005, 23(10):1443-1452[IF: 7.6]

[20] Liao H, Duka T, Teng FY, Sun L, Bu W, Ahmed S, Tang BL and  Z.C. Xiao  Nogo-66 and  myelin- associated glycoprotein (MAG) inhibit the adhesion and migration of Nogo-66 receptor expressing human glioma cells. J.Neurochem 2004,  90(5)： 1156－62  [IF: 4.2]

3.承擔(dān)的科研項(xiàng)目：

1、主持江蘇自然科學(xué)基金：神經(jīng)抑制分子經(jīng)由小膠質(zhì)細(xì)胞后對(duì)神經(jīng)生長(zhǎng)的影響，BK2006150；2006.9-2008.9

2、主持江蘇國(guó)際合作項(xiàng)目：作用于HNK-1的神經(jīng)退變病的藥物篩選，BZ2006050；2006.9-2008.9

3、主持江蘇省留學(xué)歸國(guó)人員科技活動(dòng)項(xiàng)目擇優(yōu)資助項(xiàng)目微環(huán)境因素對(duì)膠質(zhì)瘤干細(xì)胞增殖的影響及機(jī)制研究,2007－2007

4、參與國(guó)家教育部高等學(xué)�？萍紕�(chuàng)新工程重大項(xiàng)目培育基金糖原代謝異常相關(guān)

5、主持國(guó)家自然科學(xué)基金：中樞神經(jīng)損傷后小膠質(zhì)細(xì)胞對(duì)神經(jīng)元存活和神經(jīng)生長(zhǎng)的影響及機(jī)制研究，30670793；2007.1-2009.12

6、參與“十一五”國(guó)家“重大新藥創(chuàng)制”科技重大專項(xiàng)：新藥篩選核心技術(shù)規(guī)范化平臺(tái)建設(shè)及其科學(xué)應(yīng)用。2009ZX093022009-2010

7、主持江蘇自然科學(xué)基金：新型抗阿爾茨海默氏病藥物的合成和生物活性研究BK20092962009-2012

8、參與國(guó)家自然科學(xué)基金：新型抗阿爾茨海默氏病藥物的設(shè)計(jì)、合成和生物活性研究30973608/H30012010-2012

9、主持國(guó)家自然科學(xué)基金：NgR調(diào)節(jié)神經(jīng)膠質(zhì)細(xì)胞參與神經(jīng)炎癥的作用及分子機(jī)制研究81070967/H09092011-2013

10、參與“十一五”國(guó)家“重大專項(xiàng)”新型抗癌候選藥物ZCV14-2的研究2009ZX09103-090800150

11、主持國(guó)家自然科學(xué)基金：Nogo66/NgR通路介導(dǎo)的神經(jīng)炎癥在阿爾茨海默氏病發(fā)病機(jī)制中作用研究81271338/H09092013.1-2016.12

12、主持教育部高等學(xué)校博士學(xué)科點(diǎn)專項(xiàng)科研基金-博導(dǎo)類：NgR受體對(duì)阿爾茨海默病中小膠質(zhì)細(xì)胞吞噬和降解Aβ的影響及機(jī)制研究20130096110011

三、聯(lián)系方式：

地址：中國(guó)藥科大學(xué)藥物科學(xué)研究院新藥篩選中心

辦公室：中國(guó)藥科大學(xué)本部科研大樓613

E-mail:lh_sophie@aliyun.com

電話：025-8327104313705185128

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