中國(guó)藥科大學(xué)

曹征宇，男，教授，博士生導(dǎo)師。1999年畢業(yè)于南京大學(xué)和中國(guó)藥科大學(xué)聯(lián)辦生物工程制藥強(qiáng)化班，2004年畢業(yè)于中國(guó)協(xié)和醫(yī)科大學(xué)，中國(guó)醫(yī)學(xué)科學(xué)院藥物研究所，獲博士學(xué)位。2004起先后在美國(guó)University of Georgia, Creighton University, University of California, Davis 任博士后，助理教授和項(xiàng)目科學(xué)家。2013年底回國(guó)工作，現(xiàn)任中國(guó)藥科大學(xué)中藥學(xué)院教授。主要研究方向?yàn)樯窠?jīng)藥理和神經(jīng)毒理。先后參與多項(xiàng)NIH資助項(xiàng)目，目前主持國(guó)家自然科學(xué)基金面上項(xiàng)目（81473539）、江蘇省面上項(xiàng)目（BK20141357）、及天然藥物活性組分與藥效國(guó)家重點(diǎn)實(shí)驗(yàn)室杰出青年人才基金項(xiàng)目（SKLNMZZJQ201402）各一項(xiàng)，并作為Co-Investigator承擔(dān)NIH/NINDS關(guān)于抗癲癇藥物研究項(xiàng)目(課題總資助$1,700萬(wàn)，1U54 NS079202)，已在國(guó)際著名雜志發(fā)表30余篇研究論文。曹征宇博士目前擔(dān)任Genetic Disorders & Gene Therapy，International Journal of Stem Cell Research and Transplantation，Austin Journal of Allergy的編委，并常年審理來(lái)自JPET, Toxicological Sciences, NeuroToxicology等雜志的稿件。

本科題組研究方向集中于：1，建立體外多靶點(diǎn)神經(jīng)系統(tǒng)活性物質(zhì)，以及心血管系統(tǒng)活性物質(zhì)快速發(fā)現(xiàn)平臺(tái)；建立離子通道配體快速篩選方法；2，從天然產(chǎn)物中尋找用于治療神經(jīng)性疼痛，癲癇以及抗心律失常等疾病的先導(dǎo)化合物；3，天然藥物作用靶點(diǎn)以及作用機(jī)制的研究，并研究中藥單方或復(fù)方中各主要成份藥理活性的協(xié)同，疊加或者拮抗作用；4，神經(jīng)系統(tǒng)重大疾病的病理學(xué)基礎(chǔ)以及治療方案的研究：主要集中于小兒孤僻癥的發(fā)病機(jī)制以及外界因素對(duì)發(fā)病率的影響。

近期發(fā)表的代表性研究論文

1.Nichole Coleman¶, Hai M. Nguyen¶, Zhengyu Cao, Brandon M. Brown, David Paul Jenkins,DorotaZolkowska, Yi-Je Chen, Brian S. Tanaka, Alan L. Goldin, Michael A. Rogawski, Isaac N. Pessah, Heike Wulff* The Riluzole Derivative2-Amino-6-trifluoromethylthio-benzothiazole (SKA-19), aMixed KCa2 Activator and NaV Blocker, is a Potent Novel Anticonvulsant. NeuroTherapeutics, In Press.

2.Zhengyu Cao, Yanjun Cui, Eric Busse, SuneetMehrotra, Jon D. Rainier, andThomas F. Murray*Gambierol inhibition of voltage-gatedpotassium channels augmentsspontaneous Ca2+ oscillations incerebrocortical neurons. Journal of Pharmacology and Experimental Therapeutics, 2014, 350(3), 615-623.

3.Zhengyu Cao,Yanjun Cui, Hai M. Nguyen, David Paul Jenkins, Heike Wulff, Isaac N. Pessah*. NanomolarBifenthrin Alters Synchronous Ca2+ Oscillations And Cortical Neuron Development Independent of Sodium Channel Activity,Molecular Pharmacology, 2014, 85(4), 630-639.

4.Dalyir I. Pretto, Madhur Kumar, Zhengyu Cao, Chris Cunningham, Blythe Durbin, Hong Li, Robert Berman, Stephen Noctor, Randi J Hagerman, Isaac N. Pessah and Flora Tassone*. Reduced EAAT1and mGluR5expression in the cerebellum of carriers of FMR1premutation alleles.Neurobiology of Aging. 2104, 35(5), 1189-1197.

5.Zhengyu Cao*, Susan Hulsizer, Yanjun Cui, Kyungho Kim, Flora Tassone, Paul J Hagerman,and Issac N Pessah. Enhanced Asynchronous Ca2+ Oscillations Associated with Impaired Glutamate Transport In Cortical Astrocytes Expressing Fmr1Premutation Expansion. Journal of Biological Chemistry, 2013, 288(19), 13831-13841 (*, corresponding author).

6.Eitan S. Kaplanǂ, ZhengyuCaoǂ (Equal contribution), Susan Hulsizer, Robert F. Berman, Paul J. Hagerman, and Isaac N. Pessah*. Early mitochondrial abnormalities in hippocampal neurons cultured from FMR1premutation mouse model. Journal of Neurochemistry, 2012, 123(4):613-621.

7.Zhengyu Cao, Bruce D. Hammock, Mark McCoy, Pamela J. Lein, Michael A. Rogawski, and Isaac N. Pessah*.Tetramethylenedisulfotetramine Alters Ca2+ Dynamics in Cultured Hippocampal Neurons: Mitigation by NMDA Receptor Blockade and GABAA Receptor Positive Modulation.Toxicological Sciences, 2012, 130 (2):362-372.

8.Jing Liuǂ, KatarzynaKoscielskaǂ, ZhengyuCaoǂ (Equal contribution), Susan Hulsizer, Natalie Grace, Gaela Mitchel, Catherine Nacey, Jeannine McGee, Randi J Hagerman, Jan Nolta, Isaac Pessah, Paul J Hagerman*. Signaling defects in iPSC-derived fragile X premutation neurons. Human Molecular Genetics, 2012, 21 (17), 3795-3805.

9.Zhengyu Cao, Susan Hulsizer, Flora Tassone, Hiu-tung Tang, Randi J. Hagerman, Michael A. Rogawski, Paul J. Hagerman, and Isaac N. Pessah*.Clustered Burst Firing in FMR1 Premutation Hippocampal Neurons: Amelioration with Allopregnanolone. Human Molecular Genetics, 2012, 21(13); 2923-2935.

10.Nunnery, Joshawna K.; Engene, Niclas; Byrum, Tara; Cao, Zhengyu; Jabba, Sairam V.; Pereira, Alban R.; Matainaho, Teatulohi; Murray, Thomas F.; Gerwick, William H*. Biosynthetically-intriguing chlorinated lipopeptides and a pyranone from geographically distant tropical marine cyanobacteria. Journal of Organic Chemistry, 2012, 77(9):4198-4208.

11.Malloy KL, Suyama TL, Engene N, Debonsi H, Cao Z, Matainaho T, Spadafora C, Murray TF, Gerwick WH*. Credneramides A and B: Neuromodulatory Phenethylamine and Isopentylamine Derivatives of a Vinyl Chloride-Containing Fatty Acid from cf. Trichodesmium sp.nov.Journal of Natural Products, 2012, 75(1), 60-66.

12.Zhengyu Cao, Timothy J. Shafer, Chris Gennings and Thomas F. Murray*. Additivity of Pyrethroid Actions on Sodium Influx in Cortical Neurons.Environmental Health Perspective, 2011,119(9) 1139-46. (Featured article).

13.Zhengyu Cao, Timothy J. Shafer and Thomas F. Murray*. Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx into neocortical neurons in vitro. Journal of Pharmacology and Experimental Therapeutics, 2011, 336, 1: 197-205.

14.Zhengyu Cao, Keith T. Lepage, Michael O. Frederick, K.C. Nicolaou and Thomas F. Murray* Involvement of caspase activation in azaspiracid-induce neurotoxicity in neocortical neurons. Toxicological Sciences, 2010, 114(2), 323-334.

15.Zhengyu Cao, William H. Gerwick, Thomas F. Murray*. Antillatoxin Is a Voltage-Gated Sodium Channel Activator That Displays Unique Efficacy in Heterologously Expressed rNav1.2, rNav1.4 and rNav1.5 Alpha Subunits. BMC Neuroscience.2010, 11: 154.

16.Alban R. Pereira, Zhengyu Cao,NiclasEngene, Irma E. Soria-Mercado, Thomas F. Murray, and William H. Gerwick*. Palmyrolide A, An Unusual Stabilized Neuroactive Macrolide from Palmyra Atoll Cyanobacteria. Organic Letters. 2010, 12: 4490-4493.

17.Alban Pereiraǂ, ZhengyuCaoǂ(Equal contribution), Thomas F. Murray and William H. Gerwick*. Hoiamide A, a Sodium Channel Activator of Unusual Architecture from a Consortium of Two Papua New Guinea Cyanobacteria. Cell |Chemistry and Biology, 2009, 16, 893-906; 1208. (Cover page article)

18.Bhaswati Sinha, Zhengyu Cao, Thomas F. Murray, and Jane V. Aldrich*. Discovery of Dermorphin-Base Affinity Labels with Subnanomolar Affinity for Mu Opioid Receptors. Journal of Medicinal Chemistry. 2009, 52(21):6814-21.

19.Irma E. Soria-Mercado, Alban Pereira-Badilla, Zhengyu Cao, Thomas F. Murray, William H. Gerwick*. Alotamide A, A Novel Neuropharmacological agent from a Marine CyanobacteriumLyngbyabouillonii. Organic Letters, 2009, 11(20):4704-7.

20.Zhengyu Cao, Joju, George, William H. Gerwick, Daniel G. Baden, Thomas F. Murray*. Influence of Lipid Soluble Gating Modifier Toxins on Sodium Channel Mediated Sodium Influx in Neocortical Neurons. Journal of Pharmacology and Experimental Therapeutics, 2008, 326: 604-613.

專利：

Michael A. Rogawski, Isaac Pessah, Zhengyu Cao, Pamela Lein, Treatment of Seizures and Epilepsy with Combinations of a Benzodiazepine and a Neurosteroid. U.S. Patent. Registration number: 46,226

獲獎(jiǎng)：

Authur E. Schwarting Award (2010): The Hoiamides, Structurally-Intriguing Neurotoxic Lipopeptides from Papua New Guinea Marine Cyanobacteria. The Society of American Pharmacogonosy.

聯(lián)系方式：

E-mail:zycao1999@hotmail.com

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