中國(guó)藥科大學(xué)

姓名：柳曉泉

性別：男

學(xué)科專(zhuān)業(yè)：藥物動(dòng)力學(xué)

職務(wù)職稱(chēng)：教授

最高學(xué)歷及畢業(yè)時(shí)間：博士、2001年于中國(guó)藥科大學(xué)藥代中心獲得博士學(xué)位

聯(lián)系方式：025-83271260

學(xué)習(xí)經(jīng)歷：1984年于南京藥學(xué)院藥學(xué)系獲學(xué)士學(xué)位

1989年于中國(guó)藥科大學(xué)獲碩士學(xué)位

2001年于中國(guó)藥科大學(xué)獲博士學(xué)位

工作經(jīng)歷：1984～1992年中國(guó)藥科大學(xué)藥理教研室任助教

1992～1996年中國(guó)藥科大學(xué)藥代中心任講師

1996～2002年中國(guó)藥科大學(xué)藥代中心任副教授

2003～至今中國(guó)藥科大學(xué)藥代中心任教授

專(zhuān)業(yè)研究方向：藥物動(dòng)力學(xué)

①具體研究領(lǐng)域：致力于藥物代謝動(dòng)力學(xué)基礎(chǔ)理論和應(yīng)用的研究，以藥物代謝動(dòng)力學(xué)新理論、新模型、新技術(shù)和新方法的研究及其在新藥開(kāi)發(fā)研究中的應(yīng)用為主要的研究方向。目前主要研究方向包括：

1．藥動(dòng)學(xué)和藥效學(xué)結(jié)合模型研究

2．創(chuàng)新藥物的藥代動(dòng)力學(xué)研究

②課題資助：目前承擔(dān)兩項(xiàng)國(guó)家自然科學(xué)基金資助項(xiàng)目

③所獲成果：2004年獲得江蘇省科技進(jìn)步一等獎(jiǎng)一項(xiàng)（創(chuàng)新藥物體內(nèi)吸收、代謝、分布與排泄新理論與新模型研究）；2007年獲得國(guó)家科技進(jìn)二等獎(jiǎng)一項(xiàng)（臨床前藥物代謝動(dòng)力學(xué)關(guān)鍵技術(shù)與研究體系）；

④研究生培養(yǎng)：培養(yǎng)碩士研究生25名，目前在讀碩士11名；培養(yǎng)博士研究生4名，目前在讀博士生4名。

⑤近期代表性論文及成果等：

1.Hua He,, Xi Li, Haidong Wang, Wenting Zhang, Huiyong Jiang,Shijun Wang,Linhua Yuan, Yao Liu, and Xiaoquan LiuEffects of Salvianolic Acid A on Plasma and Tissue Dimethylarginine Levels in a Rat Model of Myocardial Infarction J Cardiovasc Pharmacol 2013：61：482-488

2.Hua He, Shijun Wang, Xi Li, Haidong Wang, Wenting Zhang, Linhua Yuan, Xiaoquan Liu A novel metabolic balance model for describing the metabolic disruption of and interactions between cardiovascular-related markers during acute myocardial infarction  Metabolism 2013；62：1357-1366

3.Chen Y, Cao Y, Zhou J, Liu X  Mechanism-based pharmacokinetic- pharmacodynamic  modeling of bidirectional effect of danshensu on plasma homocysteine in rats.  Pharm Res 2009 ;26(8):1863-73.

4.Cao Y, Chai JG, Chen YC, Zhao J, Zhou J, Shao JP, Ma C,Liu XD,Liu XQ  Beneficial effects of danshensu, an active component of silvia miltiorrhiza, on homocysteine metabolism via the trans-sulphuration  pathway in rat. Br J Pharmacol 2009;157(3):482-90

5． Wang H, Ma C, Zhou J, Liu XQ.Stereoselective analysis of tiopronin enantiomers in rat plasma using high-performance liquid chromatography-electrospray ionization mass spectrometry after chiral derivatization.  Chirality 2009;21(5):531-8.

6．Cao YG, Zhang L，Ma C, Chang BB, Chen YC, Tang YQ, Liu XD, Liu XQ  Metabolism of protocatechuic acid influence fatty acid oxidation in rat heart: new anti-angina mechanism implication Biochem Pharmacol 2009;77(6):1096-1104

7． Cao YG, Chen YC，Hao K , Zhang M, Liu XQ  An in vivo approach for globally estimation the drug flow between blood and tissue foe nafamostat mesilate: the main hydrolysis site determination in human. Biol Pharm Bull 2008;35(11): 1985-1989.

8．Wang H, Chen Y, Zhou J, Ma C, Chen YC, Liu XQ. Stereoselective determination of ornidazole enantiomers in human plasma and urine samples by chiral LC: application to pharmacokinetic study  Chromatographia 2008;67(11/12):875-881

9． Cao YG, Zhang M, Yu D, Shao JP, Chen YC, Liu XQ  A method for quantifying the unstable and highly polar drug nafamostat mesilate in human plasma with optimized solid-phase extraction and ESI-MS detection: more accurate evaluation for pharmacokinetic study. Anal Bioanal Chem. 2008;391 (3):1063-71.

10．Hao K, Liu XQ, Wang GJ， Zhao XP  Pharmacokinetics, tissue distribution and excretion of gambogic acid in rat. Eur J Drug Metab Pharmacokinet 2007;32(2):63-68

11．Ge lin, Jun Tang, Xiaoquan Liu, Yang Jian and Jiang Zheng Deacetylclivorine: a gender-selective metabolite of clivorine formed in female Sprague-Dawley rat liver microsomes.  Drug Metab Dispos,2007;35(4):607-613

12．Hao K, Zhao XP, Liu XQ, Wang GJ   Determination of gambogic acid in dog plasma by high-performance liquid chromatography for a pharmacokinetic study.  Biomed Chromatogr. 2007;21(3):279-283

13．Hao K, Chen YC, Cao YG, Liu XQ, Wang GJ Pharmacokinetic-pharmacodynamic modeling of telmisartan using an indirect response model in spontaneously hypertensive rats.  Acta Pharmacol Sin. 2007；28(5):738-43

14．Cao YG, Liu XQ, Chen YC, Hao K, Wang GJ  Warfarin maintenance dose adjustment with indirect pharmacodynamic model in rats.Eur J Pharm Sci.2007；30（2）：175-180

15．Zhao XP, Zhong J, Liu XQ, Wang GJ  CYP3A4 mediated in vitro metabolism of vinflunine in human liver Microsomes.  Acta Pharmacol Sin. 2007;28(1):118-24

16．J Zhong, X.Q. Liu, Y. Chen, X.P. Zhao, Y.S. Wang, G.J. Wang  Determination of renolazine in rat plasma by liquid chromatography- electrospray ionization mass spectrometry Chromatographia 2006;63(3/4):123-127

17．Zhao X，Liu X, Wang Y， Chen Y， Wang G  Determination of vinflunine in rat plasma by liquid chromatography- electrospray ionization mass spectrometry for a pharmacokinetic study J Pharm Biomed Anal 2006;41(3):906-911

18．Liu YT, Hao K, Liu XQ, Wang GJ.  Metabolism and metabolic inhibition of gambogic acid in rat liver microsomes.  Acta Pharmacol Sin 2006;27(9):1253-1258

19．Zhao XP, Liu XQ, Wang YS, Wang H, Wang GJ.  Pharmacokinetics, tissue distribution and excretion of vinflunine. Eur J Drug Metab Pharmacokinet 2006;31(2):59-64

20. Chen Y, Liu XQ, Zhong J, Zhao X, Wang Y, Wang G. Stereoselective pharmacokinetics of ornidazole after intravenous administration of individual enantiomers and the racemate.  Chirality 2006；18（10）：799-802

21. K Hao, XP Zhao, XQ Liu, GJ Wang  LC determination of curcumin in dog plasma for a pharmacokinetic study.  Chromatographia 2006;64(9/10):531-535

22. Yongsheng Wang, Xiaoping Zhao, Jiao Zhong, Xiaoquan Liu, Guangji Wang Simple determination of pirfenidone in rat plasma via high-performance liquid chromatography. Biomed Chromatogr 2006;20:1375-1379