中國藥科大學(xué)

劉曉東，教授，博士生導(dǎo)師。中國藥科大學(xué)藥學(xué)院副院長、中國藥理學(xué)會數(shù)學(xué)藥理學(xué)會理事、中國藥理學(xué)會藥物代謝動力學(xué)專業(yè)委員會副主任委員、江蘇省青藍(lán)工程跨世紀(jì)省級學(xué)術(shù)帶頭人培養(yǎng)對象和江蘇省“333”工程培養(yǎng)對象(第二層次）。2009年度入選江蘇高等學(xué)校優(yōu)秀科技創(chuàng)新團(tuán)隊帶頭人，享受國務(wù)院政府特殊津貼。主要研究方向：中藥藥物代謝動力學(xué)、血腦屏障與藥物轉(zhuǎn)運(yùn)、藥物相互作用和創(chuàng)新藥物的藥代動力學(xué)研究。主持7項國家自然科學(xué)基金項目，主持教育部雙語示范課程建設(shè)。發(fā)表學(xué)術(shù)論文120余篇，其中SCI論文90篇，獲得江蘇省科學(xué)技術(shù)進(jìn)步一等獎（排2）1項和國家科學(xué)技術(shù)進(jìn)步二等獎（排2）1項。在指導(dǎo)的研究生中1名博士生獲得省優(yōu)秀博士論文，2名碩士生獲得省優(yōu)秀碩士論文。

招生專業(yè)：藥物代謝動力學(xué)博士和碩士

近5年代表性論文

1.Li J, Guo HF, Liu C, Zhong ZY, Liu L*, Liu XD*. Prediction of drug disposition in diabetic patients by means of a physiologically based pharmacokinetic mode. Clin Pharmacokinet. 2015; 54: 179.

2.Jiang S, Zhao W, Chen Y, Zhong Z, Zhang M, Li F, Xu P, Zhao K, Li Y, Liu L*, Liu X*. Paroxetine decreased plasma exposure of glyburide partly via inhibiting intestinal absorption in rats Drug Metab Pharmacokinet. 2015;30:240

3.Zhang J, Zhang M, Sun B, Li Y, Xu P, Liu C, Liu L*, Liu XD*.  Hyperammonemia enhances the function and expression of P-glycoprotein an Mrp2 at the blood-brain barrier through NF-kB. J Neurochem. 2014; 131: 791.

4.Li F, Zhang M, Xu dan, Liu C, Zhong ZY, Jia LL, Hu MY, Yang Y, Liu L, Liu XD*. Co-administration of paroxetine and pravastatin  causes deregulation of glucose homeostasis in diabetic rats via enhanced paroxetine exposure. Acta Pharmacol Sin 2014; 35: 792.

5.Xu D, Li F, Zhang M, Zhang J,  Liu C, Hu MY, Zhong ZY, Jia LL, Wang DW, Wu J, Liu L, Liu XD*. Decreased exposure of simvastatin and simvastatin acid in a rat model of type 2 diabetes. Acta Pharmacol Sin. 2014;35:1215.

6. Liu C, Hu MY, Zhang M, Li F, Li J, Zhang J, Li Y, Guo HF, Xu P, Liu L*, Liu XD*. Association of GLP-1 secretion with anti-hyperlipidemic effect of ginsenosides in high-fat diet fed rats. Metabolism. 2014; 3:1342.

7. Liu C, Zhang M, Hu MY, Guo HF, Li J, Yu YL, Jin S, Wang XT, Liu L*, Liu XD*. Increased glucagon-like peptide-1 secretion may be involved in antidiabetic effects of ginsenosides. J Endocrinol. 2013; 217:185.

8. Jin S, Wang XT, Liu L, Yao D, Liu C, Zhang M, Guo HF, Liu XD*. P-glycoprotein and multidrug resistance-associated protein 2 are oppositely altered in brain of rats with thioacetamide-induced acute liver failure. Liver Int. 2013; 33: 274.

9. Yu YL, Wang XT, Liu C, Yao D, Hu MY, Li J, Hu N, Liu L*, Liu XD*. Combined contributions of over-secreted glucagon-like peptide 1 and suppressed insulin secretion to hyperglycemia induced by gatifloxacin in rats. Toxicol Appl Pharmacol. 2013; 266: 375.

10. Guo H, Liu C, Li J, Zhang M, Hu M, Xu P, Liu L*, Liu XD*. A mechanistic physiologically based pharmacokinetic-enzyme turnover model involving both intestine and liver to predict CYP3A induction-mediated drug–drug interactions. J Pharm Sci. 2013; 102: 2819.

11.Wang J, Xia S, Weifang Xue  Xue W, Wang D, Sai Y, Liu  L,  Liu XD*. A semi- physiologically-based pharmacokinetic model characterizing mechanism-based auto-inhibition to predict stereoselective pharmacokinetics of verapamil and its metabolite norverapamil in human.  Euro J Pharm Sci. 2013;50:290.

12. Liu HY, Liu L, Li J, Duan R, Hu N, Guo HF, Zhong ZY, Liu XD*. Combined contributions of impaired hepatic CYP2C11 and intestinal breast cancer resistance protein activities and expression to increased oral glibenclamide exposure in rats with streptozotocin-induced diabetes mellitus. Drug Metab Dispos. 2012; 40: 1104.

13.YAO D, Liu L, Jin S, Li J, Liu XD*. Overexpression of multidrug resistance-associated protein 2 in the brain of pentylenetetrazole-kindled rats. Neuroscience. 2012;227:283.

14. Liu L, Yu YL, Liu C, Wang XT, Liu XD*, Xie L. Insulin deficiency induces abnormal increase in intestinal disaccharidase activities and expression under diabetic states, evidences from in vivo and in vitro study. Biochem Pharmacol. 2011; 82: 1963.

15.Yao D, Yang ZH, Liu L, Li J, Yu YL, Zhang LL, Pan X, Liu XD*, Xie L, Wang GJ.  Verapamil exerts biphasic modulation on phenobarbital transport across blood brain barrier, evidence from in vivo and in vitro study. N-S Arch Pharmacol 2011；383：393.

16.Hu N, Xie S, Liu L, Wang X, Pan X, Chen G, Zhang L, Liu H, Liu X*, Liu X, Xie L, Wang G. Opposite effect of diabetes mellitus induced by streptozotocin on oral and intravenous pharmacokinetics of verapamil in rats. Drug Metab Dispos. 2011; 39: 419.

17.Pan X, Wang P, Hu N, Liu L, Liu X*, Xie L, Wang G. A physiologically based pharmacokinetic model characterizing mechanism-based inhibition of CYP1A2 for predicting theophylline /antofloxacin interaction in both rats and humans. Drug Metab Pharmacokinet. 2011 ;26:387.

18.Jing X, Liu X, Wen T, Xie S, Yao D, Liu X*, Wang G, Xie L. Combined effect of epileptic seizure and drug induction resulted in overexpression of P-glycoprotein in brain of kindled rats. Brit J Pharmacol；Brit J Pharmacol. 2010;159;1511-22

19.Yu Y, Liu L, Wang X, Liu X, Liu X*, Xie L, Wang G. Modulation of glucagon-like peptide-1 release by berberine: In vivo and in vitro studies  Biochem Pharmacol 2010; 79: 1000

20. Liu L, YL Yu, Y Li, YW Liu, Y Liang, XD Liu*, Xie L, Wang GJ. Berberine suppresses    intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study. N-S Arch Pharmacol. 2010; 381:371.