中國(guó)藥科大學(xué)

張建軍碩士生導(dǎo)師簡(jiǎn)介

教育、工作經(jīng)歷：

1996-2000年碩士中國(guó)藥科大學(xué)藥物制劑
2002-2005年博士中國(guó)藥科大學(xué)藥物制劑
2000.11-2002.3國(guó)家藥品審評(píng)中心
2005,11-2006,8香港浸會(huì)大學(xué)訪問學(xué)者
2010.7-2011.12江蘇四環(huán)生物股份有限公司技術(shù)總監(jiān)（企業(yè)柔性人才掛職）
2013.7-2014.6美國(guó)明尼蘇達(dá)大學(xué)訪問學(xué)者
2002.4-至今中國(guó)藥科大學(xué)藥學(xué)院藥劑教研室，中國(guó)藥科大學(xué)-震元制藥制劑合作開發(fā)實(shí)驗(yàn)室負(fù)責(zé)人

主要研究方向：新制劑與新技術(shù)研究

具體研究興趣為：

1）藥物晶體工程
2）共晶及共無定型理論與技術(shù)
3）新液晶材料及其給藥系統(tǒng)
4）緩控釋制劑技術(shù)
5）納米制劑技術(shù)

基本情況：

副教授，碩士生導(dǎo)師，國(guó)家食品藥品監(jiān)督管理局藥品審評(píng)專家。2010年獲中國(guó)藥學(xué)會(huì)-石藥青年藥劑學(xué)獎(jiǎng)，2013年獲藥明康德生命化學(xué)獎(jiǎng)，2014年獲江蘇省青藍(lán)工程中青年學(xué)術(shù)帶頭人。

主持了逾40余項(xiàng)校企合作課題的研究與產(chǎn)業(yè)化，研究劑型及技術(shù)全面，在應(yīng)用技術(shù)領(lǐng)域及制劑生產(chǎn)第一線，在推動(dòng)技術(shù)創(chuàng)新和科技成果轉(zhuǎn)化等方面有非常豐富的研發(fā)經(jīng)驗(yàn)和產(chǎn)業(yè)化經(jīng)驗(yàn)。參與國(guó)家重大新藥創(chuàng)制技術(shù)平臺(tái)和多項(xiàng)重大新藥創(chuàng)制項(xiàng)目。目前已申請(qǐng)專利40余項(xiàng)，已授權(quán)16項(xiàng)，轉(zhuǎn)讓5項(xiàng)。

注重藥物制劑理論基礎(chǔ)尤其是藥物晶體學(xué)的深入研究，重視新技術(shù)、新劑型的應(yīng)用基礎(chǔ)，發(fā)表SCI論文26篇（第一作者或通訊作者），國(guó)內(nèi)EI及核心期刊論文幾十篇，《中藥制劑新劑型與新技術(shù)》的副主編，并參與編寫了《藥劑學(xué)》、《藥劑學(xué)實(shí)驗(yàn)》等多部藥劑學(xué)教材。

代表性SCI文章：

Zhang J, Gao Y, Qian S, Liu X, Zu H. Physicochemical and pharmacokinetic characterization of a spray-dried malotilate emulsion. Int J Pharm, 2011, 414(1-2):186-192.

Liu Y, Zhang J (contribution equally), Gao Y, Zhu J. Preparation and evaluation of glyceryl monooleate-coated hollow-bioadhesive microspheres for gastroretentive drug delivery. Int J Pharm, 2011, 413(1-2):103-109.

Gao Y, Qian S, Zhang J. Physicochemical and pharmacokinetic characterization of a spray-dried cefpodoxime proxetil nanosuspension. Chem Pharm Bull 2010, 58(7): 912-917.

Zhang J, Gao Y, Su F, Gong Z, Zhang Y. Interaction characteristics with bovine serum albumin and retarded nitric oxide release of ZCVI(4)-2, a new nitric oxide-releasing derivative of oleanolic acid. Chem Pharm Bull. 2011, 59(6): 734-741.

Gao Y, Zu H, Zhang J*. Enhanced dissolution and stability of adefovir dipivoxil by cocrystal formation. J Pharm Pharmacol, 2011, 63(4): 483–490.

Zhang J, Zu H, Gao Y. Formation thermodynamics of adefovir dipivoxil-saccharin co-crystals. Acta Phys Chim Sin, 2011, 27(3): 547-552.

Gao Y, Zu H, Zhang J*. Pharmaceutical cocrystals. Prog Chem, 2010,22(5): 829-836.

Gao Y, Sun WJ, Zhang J*. Optimization of preparation and property studies on glycosylated albumin as drug carrier for nanoparticles. Pharmazie, 2011, 66(7): 484-490.

Gao Y, Sun WJ, Zhang J*. Albumin as drug carriers. Prog Chem, 2011, 23(8): 168-176.

Zhang J, Li C, Gao Y. Effect of poloxamer F 127 and paeonol on GMO-based liquid crystal transformation. Acta Chim Sin, 2011, 69(13): 1503-1508.

Zhang J, Lv H, Jiang K, Gao Y*. Enhanced bioavailability after oral and pulmonary administration of baicalein nanocrystal. Int J Pharm. 2011, 420(1):180-188.

Zhang J, Zheng Z, Gao Y*, Zhang Y. Spray-dried oil-in-water emulsion to improve the intestinal absorption and oral bioavailability of ZLR-8, a nitric oxide-releasing derivative of diclofenac. J Pharm Pharmacol, 2011, 63(12):1531-1538.

Gao Y, Li L,Zhang J*, Su F, Gong Z, Lai Y, Zhang Y. Physicochemical characterization and an injection formulation study of water insoluble ZCVI4-2，a novel NO-donor anti-cancer compound. Arch Pharm Res, 2012, 35(7): 1177-1186.

Zhang J, Liu D, Huang Y, Gao Y, Qian S. Biopharmaceutics classification and intestinal absorption study of apigenin. Int J Pharm, 2012, 436(1-2): 311-317.

Gao Y, Gao J, Liu Z, Kan H, Zu H, Sun W, Zhang J*, Qian S. Coformer selection based on degradation pathway of drugs: a case study of adefovir dipivoxil-saccharin and adefovir dipivoxil-nicotinamide cocrystals. Int J Pharm, 2012, 438(1-2): 327-335

Zhang J, Tan X, Gao J, Fan W, Gao Y, Qian S. Polymorphism of lornoxicam. J Pharm Pharmacol, 2013, 65(1): 44-52.

Zhang J, Huang Y, Liu D, Gao Y, Qian S. Preparation of apigenin nanocrystals using supercritical antisolvent process for dissolution and bioavailability enhancement. Eur J Pharm Sci, 2013, 48(4–5): 740–747.

Y Gao, J Liao, X Qi, J Zhang*. Coamorphous repaglinide–saccharin with enhanced dissolution. Int J Pharm, 2013, 450(1-2): 290-295.

Ma K, Zhang Y, Kan H, Cheng L, Luo L, Su Q, Gao J, Gao Y, Zhang J*. Thermodynamic and kinetic investigation on the crucial factors affecting adefovir dipivoxil-saccharin cocrystallization. Pharm Res, 2014, 31(7): 1766-1778.

Zhang J, Fu M, Zhang M, Xu L, Gao Y. Synthesis of oxidized glycerol monooleate-chitosan polymer and its hydrogel formation for sustained release of trimetazidine hydrochloride. Int J Pharm, 2014, 465(1-2):32-41.

Guo H, Miao N, Li T, Hao J, Gao Y, Zhang J*. Pharmaceutical coamorphous-a newly defined single-phase amorphous binary system. Prog Chem, 2014, 26(2-3): 478-486.

Huang Y, Zhang B, Gao Y, Zhang J*, Shi L. Baicalein-nicotinamide cocrystal with enhanced solubility, dissolution and oral bioavailability. J Pharm Sci, 2014, 103(8):2330-2337.

Wei Y, Li L, Xi Y, Qian S, Gao Y, Zhang J*. Sustained release and enhanced bioavailability of injectable scutellarin-loaded bovine serum albumin nanoparticles. Int J Pharm, 2014. Accepted

*: corresponding author

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