中國藥科大學(xué)

徐進宜：藥學(xué)博士，教授，博導(dǎo)，中國藥科大學(xué)藥學(xué)院藥物化學(xué)教研室副主任。

研究方向：

1. 活性天然產(chǎn)物的合成、結(jié)構(gòu)優(yōu)化及生物活性研究（碩士招生方向）

2. 針對重大疾病的創(chuàng)新藥物研究（博士招生方向）

1986年畢業(yè)于中國藥科大學(xué)，留校任教29年，一直工作在教學(xué)科研第一線，先后講授了藥物化學(xué)、藥物合成反應(yīng)、藥物分子設(shè)計、藥學(xué)英語、專業(yè)英語等課程。協(xié)助指導(dǎo)和獨立指導(dǎo)過博士、碩士研究生50余名。在國內(nèi)外期刊發(fā)表論文100余篇，其中SCI論文70余篇；申請國內(nèi)外發(fā)明專利20余項，授權(quán)14項；參編著作10部。獲得“教書育人”優(yōu)秀教師獎；教育部優(yōu)秀青年教師；國家科技部優(yōu)秀論文二等獎；廣東省科學(xué)技術(shù)獎勵一等獎；中國藥科大學(xué)先進科技工作者等榮譽。

擔(dān)任國家863計劃評審專家、國家自然科學(xué)基金評審專家、農(nóng)業(yè)部獸藥審評、江蘇省新藥審評專家；擔(dān)任Journal of Medicinal Chemistry, Current Medicinal Chemistry，European Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry等國際雜志特約審稿人。

研究經(jīng)歷包括：天然活性產(chǎn)物23-羥基白樺酸的結(jié)構(gòu)改造、生物活性與構(gòu)效關(guān)系研究；喜樹堿類分子結(jié)構(gòu)修飾與生物活性研究；天然活性產(chǎn)物XJP全合成及其類似物的新藥設(shè)計研究；冬凌草甲素的結(jié)構(gòu)改造與生物活性研究；四環(huán)二萜類活性天然產(chǎn)物化合物庫的構(gòu)建、生物學(xué)評價及作用機制研究；非肽類血管緊張素II受體拮抗劑的設(shè)計與合成研究；AT1受體拮抗劑類新藥氯沙坦、依貝沙坦、坎地沙坦的合成工藝研究；血管緊張素AT1受體和內(nèi)皮素ETA受體雙重拮抗劑研究；新型抗高血壓藥物及抗心衰藥物ATPT的研究；選擇性環(huán)氧化酶II抑制劑的研究；非苯二氮卓類GABAA受體激動劑的研究；COX-2/5-LOX雙重抑制劑的研究；手性O(shè)cotillol型人參皂苷結(jié)構(gòu)修飾衍生物的設(shè)計與合成研究；β-欖香烯結(jié)構(gòu)修飾衍生物的設(shè)計合成與構(gòu)效關(guān)系研究；在日本近畿大學(xué)完成了天然活性產(chǎn)物Gregatin B的全合成及結(jié)構(gòu)修飾研究。

負(fù)責(zé)承擔(dān)了十一五“重大新藥創(chuàng)制”、國家自然科學(xué)基金、國家科技支撐計劃、教育部科學(xué)技術(shù)研究重點項目、高等學(xué)校博士學(xué)科點專項科研基金、長三角科技攻關(guān)、江蘇省自然科學(xué)基金、江蘇省醫(yī)藥科技攻關(guān)等國家和省部級項目的研究。

近期研究成果代表性SCI論文（總影響因子大于115），均為通訊作者。

(1)Jie Liu, Hao Ren, Jinyi Xu*, Renren Bai, Qi Yan, Wenlong Huang, Xiaoming Wu*, Jihua Fu, Qiujuan Wang, Qian Wu, Rong Fu. Total synthesis and antihypertensive activity of 7,8-dihydroxy-3-methyl-isochromanone-4. Bioorg. & Med. Chem. Lett., 2009, 19: 1822-1824. (IF 2.661)

(2)Peiqing Zhu, Yi Bi, Jinyi Xu*, Zan Li, Jun Liu, Luyong Zhang, Wencai Ye, Xiaoming Wu*. Terpenoids. III: Synthesis and biological evaluation of 23-hydroxybetulinic acid derivatives as novel inhibitors of glycogen phosphorylase. Bioorg. & Med. Chem. Lett., 2009, 19: 6966–6969. (IF 2.661)

(3)Bo Jiang, Yi Zeng, Jinyi Xu*, Yongna Zhang, Qiujuan Wang, Niyue Sun, Tao Lu, and Xiaoming Wu. Design, Synthesis, and Biological Evaluation of 1, 5-Diarylsubstitued-1, 2, 4-triazole Derivatives as Selective Cyclooxygenase-2 Inhibitors. Archiv der Pharmazie, 2010, 9:500-508. (IF 1.708)

(4)Yiyun Wang, Ziyuan Li, Yue Huang, Changhua Tang, Xiaoming Wu, Jinyi Xu*, Hequan Yao*. Copper (II)-catalyzed oxidation of 4-carboxythiazolines and 4-carboxyoxazolines to 4-carboxythiazoles and 4-carboxyoxazoles. Tetrahedron. 2011, 67, 7406-7411. (IF 3.025)

(5)Shang Li, Hequan Yao, Jinyi Xu*, Sheng Jiang*. Synthetic Routes and Biological Evaluation of Largazole and Its Analogues as Potent Histone Deacetylase Inhibitors. Molecules. 2011, 16, 4681-4694. (IF 2.386)

(6)Lei Wang, Dahong Li, Yihua Zhang*, Jinyi Xu*. Recent progress in the development of natural ent-kaurane diterpenoids with anti-tumor activity. Mini-Rev. Med. Chem. 2011, 11, 910-919. (IF 2.528)

(7)Chao Lei Wang, Bing-Feng Sun*, Shu-Guang Chen, Rui Ding, Guo-Qiang Lin*, Jin-yi Xu*, Yong-Jia Shang. Concise Formal Synthesis of (+)-Englerin A and Total Synthesis of (–)-Orientalol F: Establishment of the Stereochemistry of the Organocatalytic [4+3]-Cycloaddition Reaction. Synlett, 2012, 23, 263–266. (IF 2.710)

(8)Dahong Li, Lei Wang, Hao Cai, Yihua Zhang*, Jinyi Xu*. Synthesis and biological evaluation of novel furozan-based nitric oxide-releasing derivatives of oridonin as potential anti-tumor agents. Molecules, 2012, 17, 7556-7568. (IF 2.386)

(9)Fei Sun, Peiqing Zhu, Hequan Yao, Xiaoming Wu*, Jinyi Xu*. A partial synthesis of 23-hydroxybetulonic acid and 23-hydroxybetulinic acid starting from betulinic acid. J. Chem. Res., 2012, 36(5): 254-257. (IF 0.921)

(10)Yi Bi, Jinyi Xu*, Fei Sun, Xiaoming Wu*, Wencai Ye, Yijun Sun and Wenwen Huang.  Synthesis and biological activity of 23-hydroxybetulinic acid C-28 ester derivatives as antitumor agent candidates. Molecules, 2012, 17(8): 8832-8841. (IF 2.386)

(11)Renren Bai, Xue Yang, Yao Zhu, Zhiwen Zhou, Weijia Xie, Hequan Yao, Jieyun Jiang, Jie Liu*, Mingqin Shen, Xiaoming Wu, Jinyi Xu*. Novel nitric oxide-releasing isochroman-4-one derivatives: Synthesis and evaluation of antihypertensive activity. Bioorg. & Med. Chem., 2012, 20 (23): 6848-6855. (IF 2.921)

(12)Renren Bai, Zhen Wei, Jie Liu, Weijia Xie, Hequan Yao, Xiaoming Wu*, Jieyun Jiang, Qiujuan Wang and Jinyi Xu*. Synthesis and biological evaluation of 4′-[(benzimidazole-1-yl)methyl] biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists. Bioorg. & Med. Chem., 2012, 20 (15): 4661-4667. (IF 2.921)

(13)Renren Bai, Jie Liu, Yao Zhu, Xue Yang, Chen Yang, Lingyi Kong, Xiaobing Wang, Hengyuan Zhang, Hequan Yao, Mingqin Shen, Xiaoming Wu*, Jinyi Xu*. Chiral separation, configurational identification and antihypertensive evaluation of (±)-7,8-dihydroxy-3-methyl-isochromanone-4. Bioorg. & Med. Chem. Lett., 2012, 22 (20), 6490-6493. (IF 2.661)

(14)Lei Wang, Dahong Li, Shengtao Xu, Hequan Yao, Yihua Zhang*, Jieyun Jiang, Jinyi Xu* . The conversion of oridonin to spirolactone-type or enmein-type diterpenoid: synthesis and biological evaluation of ent-6,7-seco-oridonin derivatives as novel potential anticancer agents. Eur. J. Med. Chem. 2012, 52, 242-250. (IF 3.499) 

(15)Xiaoli Wang, Qian Zhao, Xuliang Wang, Tingting Li, Yisheng Lai, Sixun Peng, Hui Ji, Jinyi Xu* and Yihua Zhang*. Studies on the enantiomers of ZJM-289: synthesis and biological evaluation of antiplatelet, antithrombotic and neuroprotective activities. Organic & Biomolecular Chemistry, 2012, 10(45): 9030-9040. (IF 3.696)

(16)Dahong Li, Hao Cai, Bowen Jiang, Guyue Liu, Yuetong Wang, Lei Wang, Hequan Yao, Xiaoming Wu*, Yijun Sun, Jinyi Xu*. Synthesis of spirolactone-type diterpenoid derivatives from kaurene-type oridonin with improved antiproliferative effects and their apoptosis-inducing activity in human hepatoma Bel-7402 cells. Eur. J. Med. Chem. 2013, 59, 322-328. (IF 3.499)

(17)Xiaoli Wang, Linna Wang, Zhangjian Huang, Tingting Li, Hui Ji, Jinyi Xu*, Yihua Zhang*. Synthesis and biological evaluation of nitric oxide releasing derivatives of  6-amino-3-n-butyl phthalide as potential antiplatelet agents. Bioorg Med Chem Lett, 2013, 1985-1988. (IF 2.921)

(18)Renren Bai, Xue Yang, Wen Hong, Yiqun Tang, Hequan Yao, Jieyun Jiang, Jie Liu, Mingqin Shen, Xiaoming Wu*, Jinyi Xu*. Novel hybrids of natural isochroman-4-one bearing N-substituted isopropanolamine as potential antihypertensive candidates. Bioorg. & Med. Chem., 2013, 21: 2495-2502. (IF 2.921)

(19)Shengtao Xu, Yu Zhou, Jinyi Xu*, Hualiang Jiang, Hong Liu*. Gold-catalyzed Michael Addition/Intramolecular Annulation Cascade: an Effective Pathway for the Chemoselective and Regioselective Synthesis of Tetracyclic Indole Derivatives in Water. Green Chem., 2013, 15, 718-726. (IF 6.320)

(20)Xiaoli Wang, Linna Wang, Tingting Li, Zhangjian Huang, Yisheng Lai, Hui Ji, Xiaolong Wan, Jinyi Xu*, Yihua Zhang*. Novel Hybrids of Optically Active Ring-Opening 3-n-Butylphthalide Derivative and Isosorbide as Potential Anti-Ischemic Stroke Agents. J Med. Chem., 2013, 56, 3078-3089. (IF 5.614)

(21)Dahong Li, Shengtao Xu, Hao Cai, Lingling Pei, Lei Wang, Hequan Yao, Xiaoming Wu*, Jieyun Jiang, Yijun Sun, Jinyi Xu*. Library construction and biological evaluation of novel enmein-type diterpenoid analogs as potential anticancer agents. Chem .Med. Chem., 2013, 8: 812-818. (IF 3.151)

(22)Dahong Li, Shengtao Xu, Hao Cai, Lingling Pei, Hengyuan Zhang, Lei Wang, Hequan Yao, Xiaoming Wu*, Jieyun Jiang, Yijun Sun, Jinyi Xu*. Enmein-type diterpenoid analogs from natural kaurene-type oridonin: synthesis and their antitumor biological evaluation Eur. J. Med. Chem. 2013, 64, 215-221. (IF 3.499)

(23)Ziwen Zhou, Cong Ma, Hengyuan Zhang, Y Bi, Xia Chen, Hua Tian, Xiaoni Xie, Qingguo Meng, Peter John Lewis*, Jinyi Xu*. Synthesis and Biological Evaluation of Novel Ocotillol-Type Triterpenoid Derivatives as Antibacterial Agents. Eur. J. Med. Chem. 2013, 68, 444-453. (IF 3.499)

(24)Bo Jiang, Xiaojing Huang, Hequan Yao, Jieyun Jiang, Xiaoming Wu*, Siyi Jiang, Qiujuan Wang, Tao Lu and Jinyi Xu*. Discovery of potential anti-inflammatory drugs: diaryl-1,2,4-triazoles bearing N-hydroxyurea moiety as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase. Org. Biomol. Chem., 2014, 12, 2114-2127. (IF 3.487)

(25)Chaolei Wang, Guoxiang Wei, Xue Yang, Hequan Yao, Jieyun Jiang, Jie Liu*, Mingqin Shen, Xiaoming Wu and Jinyi Xu*. First total synthesis of antihypertensive natural products S-(+)-XJP and R-(−)-XJP. Org. Biomol. Chem., 2014, 12, 7338-7344. (IF 3.487)

(26)Jichao Chen, Wenli Duan, Renren Bai, Hequan Yao, Jing Shang*, Jinyi Xu*. Design, synthesis and antioxidant activity evaluation of novel β-elemene derivatives. Bioorg. Med. Chem. Lett., 2014, 24, 3407–3411. (IF 2.331)

(27)Shengtao Xu, Dahong Li, Lingling Pei, Hong Yao, Chengqian Wang, Hao Cai, Hequan Yao, Xiaoming Wu, Jinyi Xu*. Design, synthesis and antimycobacterial activity evaluation of the compounds derived from natural oridonin. Bioorg. Med. Chem. Lett. 2014, 24, 2811-2814. (IF 2.331)

(28)Novel hybrids of natural oridonin bearing nitrogen mustards as potential antitumor drug candidates. Shengtao Xu, Lingling Pei, Chengqian Wang, Yun-Kai Zhang, Dahong Li, Hequan Yao, Xiaoming Wu, Zhe-Sheng Chen*, Yijun Sun, Jinyi Xu*. ACS Med. Chem. Lett. 2014, 5, 797-802. (IF 3.073)

(29)Synthesis and antimycobacterial evaluation of natural oridonin and its enmein-type derivatives. Shengtao Xu, Lingling Pei, Dahong Li, Hong Yao, Hao Cai, Hequan Yao, Xiaoming Wu, Jinyi Xu*. Fitoterapia 2014, 100, 300-306. (IF 2.216)

(30)Yi Bi, Cong Ma, Hengyuan Zhang, Zhiwen Zhou,Jian Yang,Zhenlei Zhang,Qingguo Meng*, Peter J. Lewis*, Jinyi Xu*.Novel 3-Substituted Ocotillol-Type Triterpenoid Derivatives as Antibacterial Candidates. Chem. Bio.l Drug. Des., 2014, 84, 489-496. (IF 2.507)

(31)A Mannich/cyclization cascade process for the asymmetric synthesis of spirocyclic thioimidazolidineoxindoles. Hao Cai, Yu Zhou, Dong Zhang, Jinyi Xu*, Hong Liu*. Chem Commun. 2014, 50, 14771-14774. (IF 6.834)

(32)Hengyuan Zhang, Yiwei Wang, Peiqing Zhu, Jie Liu, Shengtao Xu, Hequan Yao*, Jieyun Jiang, Wencai Ye, Xiaoming Wu, Jinyi Xu*. Design, synthesis and antitumor activity of triterpenoid pyrazine derivatives from 23-hydroxybetulinic acid. Eur. J. Med. Chem. 2015, 97, 235-244. (IF 3.432)

(33)Hengyuan Zhang, Peiqing Zhu, Jie Liu, Yan Lin, Hequan Yao, Jieyun Jiang, Wencai Ye, Xiaoming Wu, Jinyi Xu*. Synthesis, in vitro and in vivo antitumor activity of pyrazole-fused 23-hydroxybetulinic acid derivatives. Bioorg. Med. Chem. Lett., 2015, 25, 728-732. (IF 2.331)

(34)Hengyuan Zhang, Fangzheng Li, Peiqing Zhu, Jie Liu, Hequan Yao, Jieyun Jiang, Wencai Ye, Xiaoming Wu, Jinyi Xu*. Synthesis and Biological Evaluation of Oxygen-containing Heterocyclic Ring-fused 23-Hydroxybetulinic Acid Derivatives as Antitumor Agents. Chem. Biol. Drug Des., 2015, doi: 10.1111/cbdd.12543. (IF 2.507)

(35)Hengyuan Zhang, Peiqing Zhu, Jie Liu, Xue Yang, Shengtao Xu, Hequan Yao*, Jieyun Jiang, Wencai Ye, Xiaoming Wu, Jinyi Xu*. Synthesis and antitumor activity of novel 3-oxo-23-hydroxybetulinic acid derivatives. Eur. J. Med. Chem. , 2014, 87, 159-167. (IF 3.432)

(36)Jie Liu, Hengyuan Zhang, Peiqing Zhu, Xiaoming Wu, Hequan Yao, Wencai Ye, Jieyun Jiang, Jinyi Xu*.Synthesis and biological evaluation of ambradiolic acid as an inhibitor of glycogen phosphorylase. Fitoterapia, 2015, 100, 50-55. (IF 2.216)

(37)Yun-Kai Zhang, Heng-Yuan Zhang, Guan-Nan Zhang, Yi-Jun Wang,Rishil J. Kathawala, Rui Si, Bhargav A. Patel, Jinyi Xu* and Zhe-Sheng Chen*. Semi-synthetic ocotillol analogues as selective ABCB1-mediated drug resistance reversal agents. Oncotarget, 2015, online. (IF 6.63)

(38)Chaolei Wang, Zheng Wu, Jia Wang, Jie Liu*, Hequan Yao, Aijun Lin, Jinyi Xu*. An efficient synthesis of 4-isochromanones via Parham-type cyclization with Weinreb amide. Tetrahedron, 2015, doi:10.1016/j.tet.2015.08. 028. (IF 2.641)

聯(lián)系方式

E-mail：jinyixu@china.com;  jinyixu@cpu.edu.cn